Literature DB >> 8576905

alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.

D R Magnin1, S A Biller, Y Chen, J K Dickson, O M Fryszman, R M Lawrence, J V Logan, E S Sieber-McMaster, R B Sulsky, S C Traeger, D C Hsieh, S J Lan, J K Rinehart, T W Harrity, K G Jolibois, L K Kunselman, L C Rich, D A Slusarchyk, C P Ciosek.   

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Year:  1996        PMID： 8576905     DOI： 10.1021/jm9507340

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  8 in total

1.  A Structural and Bioinformatics Investigation of a Fungal Squalene Synthase and Comparisons with Other Membrane Proteins.

Authors:  Satish R Malwal; Na Shang; Weidong Liu; Xian Li; Lilan Zhang; Chun-Chi Chen; Rey-Ting Guo; Eric Oldfield
Journal:  ACS Omega       Date:  2022-06-17

2.  Synthesis and biological evaluation of a phosphonate analog of the natural acetyl cholinesterase inhibitor cyclophostin.

Authors:  Saibal Bandyopadhyay; Supratik Dutta; Christopher D Spilling; Cynthia M Dupureur; Nigam P Rath
Journal:  J Org Chem       Date:  2008-09-27       Impact factor: 4.354

3.  A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.

Authors:  Chia-I Liu; George Y Liu; Yongcheng Song; Fenglin Yin; Mary E Hensler; Wen-Yih Jeng; Victor Nizet; Andrew H-J Wang; Eric Oldfield
Journal:  Science       Date:  2008-02-14       Impact factor: 47.728

4.  Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.

Authors:  Yongcheng Song; Chia-I Liu; Fu-Yang Lin; Joo Hwan No; Mary Hensler; Yi-Liang Liu; Wen-Yih Jeng; Jennifer Low; George Y Liu; Victor Nizet; Andrew H-J Wang; Eric Oldfield
Journal:  J Med Chem       Date:  2009-07-09       Impact factor: 7.446

5.  Role of rsbU and staphyloxanthin in phagocytosis and intracellular growth of Staphylococcus aureus in human macrophages and endothelial cells.

Authors:  Aurélie C Olivier; Sandrine Lemaire; Françoise Van Bambeke; Paul M Tulkens; Eric Oldfield
Journal:  J Infect Dis       Date:  2009-11-01       Impact factor: 5.226

6.  2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.

Authors:  Carlos A Rodrígues-Poveda; Dolores González-Pacanowska; Sergio H Szajnman; Juan B Rodríguez
Journal:  Antimicrob Agents Chemother       Date:  2012-05-14       Impact factor: 5.191

7.  Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.

Authors:  Yongcheng Song; Fu-Yang Lin; Fenglin Yin; Mary Hensler; Carlos A Rodrígues Poveda; Dushyant Mukkamala; Rong Cao; Hong Wang; Craig T Morita; Dolores González Pacanowska; Victor Nizet; Eric Oldfield
Journal:  J Med Chem       Date:  2009-02-26       Impact factor: 7.446

Review 8.  Human isoprenoid synthase enzymes as therapeutic targets.

Authors:  Jaeok Park; Alexios N Matralis; Albert M Berghuis; Youla S Tsantrizos
Journal:  Front Chem       Date:  2014-07-22       Impact factor: 5.221
  8 in total

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