| Literature DB >> 8575774 |
Y Yamada1, T Hayami, K Nakamura, P J Kaisaki, Y Someya, C Z Wang, S Seino, Y Seino.
Abstract
Gastric inhibitory polypeptide (GIP), which is released from the gastrointestinal tract, stimulates insulin secretion from pancreatic beta cells and plays a crucial role in the regulation of insulin secretion during the postprandial phase. We have isolated the human gene (GIPR) and cDNA encoding the GIP receptor by a combination of the conventional screening and polymerase chain reaction procedures. Human GIP receptor cDNA encodes a protein of 466 amino acids that is 81.5 and 81.2% identical to the previously cloned hamster and rat GIP receptor, respectively. Hydropathic analysis shows the presence of a signal peptide and seven potential transmembrane domains, a feature characteristic of the VIP/glucagon/secretin receptor family of G protein-coupled receptors. The human GIPR gene is about 13.8 kb long, consists of 14 exons, and carries 17 Alu repeats.Entities:
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Year: 1995 PMID： 8575774 DOI： 10.1006/geno.1995.9937
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736