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Literature DB >> 8575766

The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28.

U C Rogner¹, K Wilke, E Steck, B Korn, A Poustka.

Abstract

The melanoma antigen gene (MAGE) family comprises 12 known genes, of which 6 are expressed in tumors. In the course of a systematic analysis of transcripts in Xq28, we have identified cDNAs related to different MAGE genes. Analysis of cell hybrids, ordered YACs, and cosmids showed that all MAGE genes are located in Xq28 and are clustered in three main intervals within 3.5 Mb. The six genes expressed in tumors are contained in the two intervals closest to the telomere and are highly homologous to each other. Analysis of different species suggests that human MAGE sequences are conserved in primates, but less well conserved in other vertebrate species.

Entities: Disease Gene Species

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Year: 1995 PMID： 8575766 DOI： 10.1006/geno.1995.9945

Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736

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Cited

30 in total

1. Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes.

Authors: Montserrat C Anguera; Ruslan Sadreyev; Zhaoqing Zhang; Attila Szanto; Bernhard Payer; Steven D Sheridan; Showming Kwok; Stephen J Haggarty; Mriganka Sur; Jason Alvarez; Alexander Gimelbrant; Maisam Mitalipova; James E Kirby; Jeannie T Lee
Journal: Cell Stem Cell Date: 2012-07-06 Impact factor: 24.633

2. The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

Authors: C De Smet; O De Backer; I Faraoni; C Lurquin; F Brasseur; T Boon
Journal: Proc Natl Acad Sci U S A Date: 1996-07-09 Impact factor: 11.205

3. Induction of MAGE-A3 and HPV-16 immunity by Trojan vaccines in patients with head and neck carcinoma.

Authors: Caroline J Voskens; Duane Sewell; Ronna Hertzano; Jennifer DeSanto; Sandra Rollins; Myounghee Lee; Rodney Taylor; Jeffrey Wolf; Mohan Suntharalingam; Brian Gastman; John C Papadimitriou; Changwan Lu; Ming Tan; Robert Morales; Kevin Cullen; Esteban Celis; Dean Mann; Scott E Strome
Journal: Head Neck Date: 2012-01-27 Impact factor: 3.147

4. Increased expression of androgen receptor coregulator MAGE-11 in prostate cancer by DNA hypomethylation and cyclic AMP.

Authors: Adam R Karpf; Suxia Bai; Smitha R James; James L Mohler; Elizabeth M Wilson
Journal: Mol Cancer Res Date: 2009-04 Impact factor: 5.852

Review 5. Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy.

Authors: Pierre G Coulie; Benoît J Van den Eynde; Pierre van der Bruggen; Thierry Boon
Journal: Nat Rev Cancer Date: 2014-02 Impact factor: 60.716

6. Comparative genome sequence analysis of the Bpa/Str region in mouse and Man.

Authors: A M Mallon; M Platzer; R Bate; G Gloeckner; M R Botcherby; G Nordsiek; M A Strivens; P Kioschis; A Dangel; D Cunningham; R N Straw; P Weston; M Gilbert; S Fernando; K Goodall; G Hunter; J S Greystrong; D Clarke; C Kimberley; M Goerdes; K Blechschmidt; A Rump; B Hinzmann; C R Mundy; W Miller; A Poustka; G E Herman; M Rhodes; P Denny; A Rosenthal; S D Brown
Journal: Genome Res Date: 2000-06 Impact factor: 9.043

10. In silico analysis of human Telomerase Reverse Transcriptase (hTERT) gene: identification of a distant homolog of Melanoma Antigen Family Gene (MAGE).

Authors: Ruhul Amin; Hasan Jamil; M Anwar Hossain
Journal: Cancer Inform Date: 2009-11-24