W Wang1, C C Pang, M S Rogers, A M Chang. 1. Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Abstract
OBJECTIVE: The purpose of this study was to determine oxygen free radical activity in the neonate at birth and relate it to umbilical cord blood acid-base status. STUDY DESIGN: A series of 110 singleton deliveries had determination of two lipoperoxides in umbilical cord blood: malondialdehyde and organic hydroperoxide. Umbilical pH, PO2, PCO2, bicarbonate, and base excess were also measured. RESULTS: There was a significant association between lipoperoxides and cord blood pH and base excess. A significant difference existed in the levels of umbilical artery lipoperoxides between nonacidemic and acidemic fetus, as defined by an umbilical arterial pH < 7.20. CONCLUSION: There is a positive association between lipoperoxide production and acid-base balance at delivery.
OBJECTIVE: The purpose of this study was to determine oxygen free radical activity in the neonate at birth and relate it to umbilical cord blood acid-base status. STUDY DESIGN: A series of 110 singleton deliveries had determination of two lipoperoxides in umbilical cord blood: malondialdehyde and organic hydroperoxide. Umbilical pH, PO2, PCO2, bicarbonate, and base excess were also measured. RESULTS: There was a significant association between lipoperoxides and cord blood pH and base excess. A significant difference existed in the levels of umbilical artery lipoperoxides between nonacidemic and acidemic fetus, as defined by an umbilical arterial pH < 7.20. CONCLUSION: There is a positive association between lipoperoxide production and acid-base balance at delivery.
Authors: Lauren M Bullens; Alexandra D J Hulsenboom; Suzanne Moors; Rohan Joshi; Pieter J van Runnard Heimel; M Beatrijs van der Hout-van der Jagt; Edwin R van den Heuvel; S Guid Oei Journal: Trials Date: 2018-03-23 Impact factor: 2.279