[Sensitivity to insulin in acute myocardial infarct].

The standard test for sensitivity of insulin was conducted in 20 patients with acute large-focal myocardial infarction, and in 9 of them it was repeated 3 weeks later. The study includes only those patients who had no diabetes mellitus symptoms prior to the admission to the clinic, and whose immediate relatives were free of this disease. The test was conducted in the morning on an empty stomach, insulin was administered intravenously by infusion of 5 U/l m2 of body surface. Blood sugar measurements were made in samples procured 10, 20, 30, 45, 60, 90 and 120 min. following insulin administration. The blood sugar level was determined by the orthotoluidine method. In patients with acute myocardial infarction less distinct and slower deceleration of the reduction of the blood sugar level was noted in response to the intravenous insulin injection than during the repeated examination on the 22nd-24th day of the disease, which indicates a decreased sensitivity of insulin during the acute period of myocardial infarction. Reduction of insulin sensitivity seems to be one of the causes of frequent carbohydrates metabolism disorders in patients with acute myocardial infarction.