Literature DB >> 8570652

Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.

D L Griffith1, P C Keck, T K Sampath, D C Rueger, W D Carlson.   

Abstract

We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.

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Year:  1996        PMID： 8570652      PMCID： PMC40151          DOI： 10.1073/pnas.93.2.878

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  Improved methods for building protein models in electron density maps and the location of errors in these models.

Authors:  T A Jones; J Y Zou; S W Cowan; M Kjeldgaard
Journal:  Acta Crystallogr A       Date:  1991-03-01       Impact factor: 2.290

2.  Three-dimensional Fourier synthesis of human deoxyhemoglobin at 2-5 A resolution I. X-ray analysis.

Authors:  L F TenEyck; A Arnone
Journal:  J Mol Biol       Date:  1976-01-05       Impact factor: 5.469

3.  Conformation of beta hairpins in protein structures: classification and diversity in homologous structures.

Authors:  B L Sibanda; J M Thornton
Journal:  Methods Enzymol       Date:  1991       Impact factor: 1.600

4.  Loops in globular proteins: a novel category of secondary structure.

Authors:  J F Leszczynski; G D Rose
Journal:  Science       Date:  1986-11-14       Impact factor: 47.728

5.  Resolution of phase ambiguity in macromolecular crystallography.

Authors:  B C Wang
Journal:  Methods Enzymol       Date:  1985       Impact factor: 1.600

6.  Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development.

Authors:  S C Chang; B Hoang; J T Thomas; S Vukicevic; F P Luyten; N J Ryba; C A Kozak; A H Reddi; M Moos
Journal:  J Biol Chem       Date:  1994-11-11       Impact factor: 5.157

7.  New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor.

Authors:  N Q McDonald; R Lapatto; J Murray-Rust; J Gunning; A Wlodawer; T L Blundell
Journal:  Nature       Date:  1991-12-05       Impact factor: 49.962

8.  The univin gene encodes a member of the transforming growth factor-beta superfamily with restricted expression in the sea urchin embryo.

Authors:  P Stenzel; L M Angerer; B J Smith; R C Angerer; W W Vale
Journal:  Dev Biol       Date:  1994-11       Impact factor: 3.582

9.  Expression pattern of osteogenic protein-1 (bone morphogenetic protein-7) in human and mouse development.

Authors:  M N Helder; E Ozkaynak; K T Sampath; F P Luyten; V Latin; H Oppermann; S Vukicevic
Journal:  J Histochem Cytochem       Date:  1995-10       Impact factor: 2.479

10.  Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates.

Authors:  S D Cook; M W Wolfe; S L Salkeld; D C Rueger
Journal:  J Bone Joint Surg Am       Date:  1995-05       Impact factor: 5.284
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  43 in total

1.  Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions.

Authors:  Thomas B Thompson; Teresa K Woodruff; Theodore S Jardetzky
Journal:  EMBO J       Date:  2003-04-01       Impact factor: 11.598

Review 2.  Pharmacologic therapy for osteoarthritis--the era of disease modification.

Authors:  David J Hunter
Journal:  Nat Rev Rheumatol       Date:  2010-11-16       Impact factor: 20.543

3.  Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.

Authors:  Y A Muller; B Li; H W Christinger; J A Wells; B C Cunningham; A M de Vos
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-08       Impact factor: 11.205

4.  Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.

Authors:  Hikaru Sugimoto; Valerie S LeBleu; Dattatreyamurty Bosukonda; Peter Keck; Gangadhar Taduri; Wibke Bechtel; Hirokazu Okada; William Carlson; Philippe Bey; Mary Rusckowski; Björn Tampe; Desiree Tampe; Keizo Kanasaki; Michael Zeisberg; Raghu Kalluri
Journal:  Nat Med       Date:  2013-07       Impact factor: 53.440

Review 5.  Structural Biology and Evolution of the TGF-β Family.

Authors:  Andrew P Hinck; Thomas D Mueller; Timothy A Springer
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-12-01       Impact factor: 10.005

6.  Design of a controlled release system of OP-1 and TGF-β1 based in microparticles of sodium alginate and release characterization by HPLC-UV.

Authors:  Ricardo Oliva-Rodríguez; José Pérez-Urizar; Estela Dibildox-Alvarado; María Consolación Martínez-Saldaña; Francisco Javier Avelar-González; Héctor Flores-Reyes; Amaury de Jesús Pozos-Guillén; Alma Lilián Guerrero-Barrera
Journal:  In Vitro Cell Dev Biol Anim       Date:  2011-10-20       Impact factor: 2.416

7.  Modeling the human intestinal mucin (MUC2) C-terminal cystine knot dimer.

Authors:  Vatsala D Sadasivan; Sandeep R Narpala; David E Budil; Albert Sacco; Rebecca L Carrier
Journal:  J Mol Model       Date:  2011-02-12       Impact factor: 1.810

8.  Novel point mutations in GDF5 associated with two distinct limb malformations in Chinese: brachydactyly type C and proximal symphalangism.

Authors:  Wei Yang; Lihua Cao; Wenli Liu; Li Jiang; Miao Sun; Dai Zhang; Shusen Wang; Wilson H Y Lo; Yang Luo; Xue Zhang
Journal:  J Hum Genet       Date:  2008-02-19       Impact factor: 3.172

9.  Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis.

Authors:  David J Hunter; Marilyn C Pike; Beth L Jonas; Eugene Kissin; Julie Krop; Tim McAlindon
Journal:  BMC Musculoskelet Disord       Date:  2010-10-10       Impact factor: 2.362

Review 10.  The biology of activin: recent advances in structure, regulation and function.

Authors:  Yin Xia; Alan L Schneyer
Journal:  J Endocrinol       Date:  2009-03-09       Impact factor: 4.286
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