| Literature DB >> 8568858 |
S Beck1, S Abdulla, R P Alderton, R J Glynne, I G Gut, L K Hosking, A Jackson, A Kelly, W R Newell, P Sanseau, E Radley, K L Thorpe, J Trowsdale.
Abstract
About 40% (350 kb) of the human MHC class II region has been sequenced and a coordinated effort to sequence the entire MHC is underway. In addition to the coding information (22 genes/pseudogenes), the non-coding sequences reveal novel information on the organisation and evolution of the MHC as demonstrated here by the example of a 200 kb contig that has been analysed for local and global features. In conjunction with cross-species comparisons, our results present new evidence on the structure of isochores, the evolutionary dynamics of repeat-mediated recombination and its effect on certain MHC encoded genes, and a higher than average degree of natural polymorphism that has implications for sequencing the human genome. We also report the finding of a class I-related pseudogene (HLA-ZI) in the middle of the class II region, which provides the first direct evidence for DNA exchange between these two related regions in man.Entities:
Mesh：
Year: 1996 PMID： 8568858 DOI： 10.1006/jmbi.1996.0001
Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469