| Literature DB >> 8568801 |
H R Howard1, J A Lowe, T F Seeger, P A Seymour, S H Zorn, P R Maloney, F E Ewing, M E Newman, A W Schmidt, J S Furman, G L Robinson, E Jackson, C Johnson, J Morrone.
Abstract
A series of substituted phenethyl derivatives of 3-benzisothiazolylpiperazine incorporating potent D2 and 5-HT2A antagonist activity was investigated as an approach to a novel atypical antipsychotic agent. The in vitro profile of 8e from this series is a combination of D2 receptor affinity comparable to the typical antipsychotic agent haloperidol and a 5-HT2A/D2 ratio comparable to the atypical agent clozapine. In vivo 8e possesses activity consistent with an efficacious antipsychotic agent with less tendency to induce extrapyramidal side effects in man.Entities:
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Year: 1996 PMID： 8568801 DOI： 10.1021/jm950625l
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446