| Literature DB >> 8567926 |
P S Eastman1, E Boyer, L Mole, J Kolberg, M Urdea, M Holodniy.
Abstract
A nonisotopic hybridization assay for human immunodeficiency virus genotypic zidovudine resistance determination is described. Biotinylated PCR product was hybridized with enzyme-labeled probes for wild-type or resistant mutant sequences and detected colorimetrically or chemiluminescently in a microplate format. Changes in mutant-to-wild-type ratios allow for the monitoring of longitudinal patient samples.Entities:
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Year: 1995 PMID: 8567926 PMCID: PMC228576 DOI: 10.1128/jcm.33.10.2777-2780.1995
Source DB: PubMed Journal: J Clin Microbiol ISSN: 0095-1137 Impact factor: 5.948