Literature DB >> 8567020

The 5' coding sequence of IL-2 receptor alpha chain mRNA mediates mRNA stabilization by HTLV-1 Rex.

H Kanamori1, T Kodama, Y Yazaki.   

Abstract

The interleukin-2 receptor alpha chain (IL-2R alpha) is a T-cell growth factor receptor and is known to be induced in helper T cells by infection with human T-cell leukaemia virus type-1 (HTLV-1). The Rex protein of HTLV-1 has been shown to stabilize IL-2R alpha mRNA. Although the 3' untranslated region of many RNA has been regarded as a key element for stabilization, we found that the first 300 bases of the IL-2R alpha protein coding sequence were necessary for stabilization of the mRNA. As the first 201 bases were not sufficient for this effect, we conclude that the bases at position 201-300 downstream of the AUG start are important for stabilization.

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Year:  1995        PMID： 8567020      PMCID： PMC1384054     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  28 in total

1.  Nucleolar targeting signal of human T-cell leukemia virus type I rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA.

Authors:  T Nosaka; H Siomi; Y Adachi; M Ishibashi; S Kubota; M Maki; M Hatanaka
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

2.  Transcriptional regulation alone does not explain the constitutive expression of the interleukin 2 receptor (Tac/L-chain) in HTLV-1 infected cells.

Authors:  H Kanamori; N Suzuki; N Ishida; T Honjo
Journal:  Immunol Lett       Date:  1989-03       Impact factor: 3.685

3.  A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.

Authors:  G Shaw; R Kamen
Journal:  Cell       Date:  1986-08-29       Impact factor: 41.582

4.  Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin.

Authors:  T J Yen; P S Machlin; D W Cleveland
Journal:  Nature       Date:  1988-08-18       Impact factor: 49.962

5.  A stem-loop in the 3' untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm.

Authors:  E W Müllner; L C Kühn
Journal:  Cell       Date:  1988-06-03       Impact factor: 41.582

6.  Cloning of cDNA for the bovine IL-2 receptor (bovine Tac antigen).

Authors:  A D Weinberg; J Shaw; V Paetkau; R C Bleackley; N S Magnuson; R Reeves; J A Magnuson
Journal:  Immunology       Date:  1988-04       Impact factor: 7.397

7.  Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering.

Authors:  M Maruyama; H Shibuya; H Harada; M Hatakeyama; M Seiki; T Fujita; J Inoue; M Yoshida; T Taniguchi
Journal:  Cell       Date:  1987-01-30       Impact factor: 41.582

8.  Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing.

Authors:  H Siomi; H Shida; S H Nam; T Nosaka; M Maki; M Hatanaka
Journal:  Cell       Date:  1988-10-21       Impact factor: 41.582

9.  HTLV-1 p27rex stabilizes human interleukin-2 receptor alpha chain mRNA.

Authors:  H Kanamori; N Suzuki; H Siomi; T Nosaka; A Sato; H Sabe; M Hatanaka; T Honjo
Journal:  EMBO J       Date:  1990-12       Impact factor: 11.598

10.  Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins.

Authors:  M Hidaka; J Inoue; M Yoshida; M Seiki
Journal:  EMBO J       Date:  1988-02       Impact factor: 11.598
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  1 in total

Review 1.  HTLV-1 Yin and Yang: Rex and p30 master regulators of viral mRNA trafficking.

Authors:  Hicham H Baydoun; Marcia Bellon; Christophe Nicot
Journal:  AIDS Rev       Date:  2008 Oct-Dec       Impact factor: 2.500
  1 in total

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