Literature DB >> 8566762

Analysis of two capreomycin-resistance determinants from Streptomyces capreolus and characterization of the action of their products.

A S Thiara1, E Cundliffe.   

Abstract

Two genes encoding capreomycin (Cp)-modifying enzymes have been isolated from the producing organism Streptomyces capreolus. Cp acetyltransferase (CAC), encoded by cac, is active against all four components of the Cp complex, whereas Cp phosphotransferase (CPH), the product of cph, is active against Cp components IA and IIA (and also the related antibiotic, Vm) but not against Cp IB or Cp IIB.

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Year:  1995        PMID： 8566762     DOI： 10.1016/0378-1119(95)00702-4

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  5 in total

Review 1.  Avoidance of suicide in antibiotic-producing microbes.

Authors:  Eric Cundliffe; Arnold L Demain
Journal:  J Ind Microbiol Biotechnol       Date:  2010-05-06       Impact factor: 3.346

Review 2.  Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria.

Authors:  Hiroshi Ogawara
Journal:  Molecules       Date:  2019-09-21       Impact factor: 4.411

3.  Identification of the biosynthetic gene cluster and an additional gene for resistance to the antituberculosis drug capreomycin.

Authors:  Elizabeth A Felnagle; Michelle R Rondon; Andrew D Berti; Heidi A Crosby; Michael G Thomas
Journal:  Appl Environ Microbiol       Date:  2007-05-11       Impact factor: 4.792

Review 4.  Tuberactinomycin antibiotics: Biosynthesis, anti-mycobacterial action, and mechanisms of resistance.

Authors:  Zane T Laughlin; Graeme L Conn
Journal:  Front Microbiol       Date:  2022-08-11       Impact factor: 6.064

Review 5.  Tetracycline-Inactivating Enzymes.

Authors:  Jana L Markley; Timothy A Wencewicz
Journal:  Front Microbiol       Date:  2018-05-30       Impact factor: 5.640
  5 in total

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