The use of trabeculectomy to study the pharmacological modulation of ophthalmic wound healing.

A trabeculectomy model was developed to test the efficacy of a putative interleukin-1 blocker on the modulation of ophthalmic wound healing in the pigmented rabbit. The corticosteroid, methylprednisolone acetate, was used as a positive control and was effective in prolonging the time to failure of the trabeculectomy. The experimental compound CK-103A was found to be more efficacious than methyl prednisolone acetate. CK-103A increased the time of failure by 79%, with no side effects at the doses tested to date.