Literature DB >> 8564216

Evidence for selective inhibition by lysophosphatidylcholine of acetylcholine-induced endothelium-dependent hyperpolarization and relaxation in rat mesenteric artery.

M Fukao1, Y Hattori, M Kanno, I Sakuma, A Kitabatake.   

Abstract

The effects of lysophosphatidylcholine (LPC) on acetylcholine-induced hyperpolarization and relaxation were examined in rat mesenteric arteries. LPC (3-10 microM) reversibly inhibited endothelium-dependent hyperpolarization by acetylcholine in a concentration-dependent manner. LPC (10 microM) inhibited only partially endothelium-dependent relaxation by acetylcholine. However, acetylcholine-induced relaxation obtained in the presence of 100 microM NG-nitro-L-arginine was almost completely eliminated by 10 microM LPC. These results indicate that LPC inhibits hyperpolarization and relaxation due to endothelium-derived hyperpolarizing factor more specifically than the relaxation due to endothelium-derived nitric oxide.

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Year:  1995        PMID： 8564216      PMCID： PMC1908897          DOI： 10.1111/j.1476-5381.1995.tb16370.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins.

Authors:  K Kugiyama; S A Kerns; J D Morrisett; R Roberts; P D Henry
Journal:  Nature       Date:  1990-03-08       Impact factor: 49.962

2.  Calcium dependency of the endothelium-dependent hyperpolarization in smooth muscle cells of the rabbit carotid artery.

Authors:  G F Chen; H Suzuki
Journal:  J Physiol       Date:  1990-02       Impact factor: 5.182

3.  Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.

Authors:  S Parthasarathy; U P Steinbrecher; J Barnett; J L Witztum; D Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

4.  Differential role of extra- and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells.

Authors:  A Lückhoff; U Pohl; A Mülsch; R Busse
Journal:  Br J Pharmacol       Date:  1988-09       Impact factor: 8.739

5.  Decreased endothelium-dependent hyperpolarization to acetylcholine in smooth muscle of the mesenteric artery of spontaneously hypertensive rats.

Authors:  K Fujii; M Tominaga; S Ohmori; K Kobayashi; T Koga; Y Takata; M Fujishima
Journal:  Circ Res       Date:  1992-04       Impact factor: 17.367

Review 6.  Endothelium-derived hyperpolarizing factor (EDHF).

Authors:  H Suzuki; G Chen; Y Yamamoto
Journal:  Jpn Circ J       Date:  1992-02

7.  Lysophosphatidylcholine inhibits bradykinin-induced phosphoinositide hydrolysis and calcium transients in cultured bovine aortic endothelial cells.

Authors:  N Inoue; K Hirata; M Yamada; Y Hamamori; Y Matsuda; H Akita; M Yokoyama
Journal:  Circ Res       Date:  1992-12       Impact factor: 17.367

8.  Lysophosphatidylcholine: essential role in the inhibition of endothelium-dependent vasorelaxation by oxidized low density lipoprotein.

Authors:  M Yokoyama; K Hirata; R Miyake; H Akita; Y Ishikawa; H Fukuzaki
Journal:  Biochem Biophys Res Commun       Date:  1990-04-16       Impact factor: 3.575

9.  Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.

Authors:  C Bossaller; G B Habib; H Yamamoto; C Williams; S Wells; P D Henry
Journal:  J Clin Invest       Date:  1987-01       Impact factor: 14.808

10.  Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

Authors:  S Ylä-Herttuala; W Palinski; M E Rosenfeld; S Parthasarathy; T E Carew; S Butler; J L Witztum; D Steinberg
Journal:  J Clin Invest       Date:  1989-10       Impact factor: 14.808
  10 in total
  4 in total

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Authors:  A Makino; K Ohuchi; K Kamata
Journal:  Br J Pharmacol       Date:  2000-06       Impact factor: 8.739

2.  Lysophosphatidylcholine potentiates vascular contractile responses in rat aorta via activation of tyrosine kinase.

Authors:  Hiroshi Suenaga; Katsuo Kamata
Journal:  Br J Pharmacol       Date:  2002-02       Impact factor: 8.739

3.  GPR55-dependent and -independent ion signalling in response to lysophosphatidylinositol in endothelial cells.

Authors:  Alexander Bondarenko; Markus Waldeck-Weiermair; Shamim Naghdi; Michael Poteser; Roland Malli; Wolfgang F Graier
Journal:  Br J Pharmacol       Date:  2010-09       Impact factor: 8.739

4.  GPR55 agonist lysophosphatidylinositol and lysophosphatidylcholine inhibit endothelial cell hyperpolarization via GPR-independent suppression of Na+-Ca2+ exchanger and endoplasmic reticulum Ca2+ refilling.

Authors:  Alexander I Bondarenko; Fabrizio Montecucco; Olga Panasiuk; Vadim Sagach; Nataliya Sidoryak; Karim J Brandt; François Mach
Journal:  Vascul Pharmacol       Date:  2017-01-05       Impact factor: 5.773
  4 in total

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