Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Lens opacification by antioestrogens: tamoxifen vs ICI 182,780.

Literature DB >> 8564190

Lens opacification by antioestrogens: tamoxifen vs ICI 182,780.

J J Zhang¹, T J Jacob, S P Hardy, C F Higgins, M A Valverde.

Abstract

The antioestrogen, tamoxifen, blocks volume-regulated chloride channels and reduces transparency in bovine lenses maintained in vitro. In contrast to tamoxifen, the steroidal antioestrogen, ICI 182780, did not block volume-regulated chloride currents in three cultured cell lines and required 10 fold higher concentration to induce significant opacification of bovine lenses maintained in vitro. These data suggest that ocular toxic side effects will be minimized by use of the steroidal (ICI 182780) rather than nonsteroidal antioestrogens (tamoxifen).

Entities: Chemical Species

Mesh：

Substances：

Year: 1995 PMID： 8564190 PMCID： PMC1908879 DOI： 10.1111/j.1476-5381.1995.tb16622.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

9 in total

Review 1. Clear evidence that long-term, low-dose tamoxifen treatment can induce ocular toxicity. A prospective study of 63 patients.

Authors: N A Pavlidis; C Petris; E Briassoulis; G Klouvas; C Psilas; J Rempapis; G Petroutsos
Journal: Cancer Date: 1992-06-15 Impact factor: 6.860

Review 2. The pharmacology and clinical uses of tamoxifen.

Authors: B J Furr; V C Jordan
Journal: Pharmacol Ther Date: 1984 Impact factor: 12.310

3. Ocular toxicity of tamoxifen.

Authors: E W Gerner
Journal: Ann Ophthalmol Date: 1989-11

Review 4. Are breast tumours resistant to tamoxifen also resistant to pure antioestrogens?

Authors: A E Wakeling
Journal: J Steroid Biochem Mol Biol Date: 1993-12 Impact factor: 4.292

5. Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer.

Authors: D J DeFriend; A Howell; R I Nicholson; E Anderson; M Dowsett; R E Mansel; R W Blamey; N J Bundred; J F Robertson; C Saunders
Journal: Cancer Res Date: 1994-01-15 Impact factor: 12.701

6. Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.

Authors: J J Zhang; T J Jacob; M A Valverde; S P Hardy; G M Mintenig; F V Sepúlveda; D R Gill; S C Hyde; A E Trezise; C F Higgins
Journal: J Clin Invest Date: 1994-10 Impact factor: 14.808

7. ATP-activated chloride channel inhibited by an antibody to P glycoprotein.

Authors: J J Zhang; T J Jacob
Journal: Am J Physiol Date: 1994-10

8. Differential effects of tamoxifen and I- on three distinguishable chloride currents activated in T84 intestinal cells.

Authors: M A Valverde; G M Mintenig; F V Sepúlveda
Journal: Pflugers Arch Date: 1993-12 Impact factor: 3.657

Review 9. Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer.

Authors: V C Jordan
Journal: Br J Pharmacol Date: 1993-10 Impact factor: 8.739

9 in total

6 in total

1. Inhibition of volume-regulated anion channels in cultured endothelial cells by the anti-oestrogens clomiphene and nafoxidine.

Authors: C Maertens; G Droogmans; P Chakraborty; B Nilius
Journal: Br J Pharmacol Date: 2001-01 Impact factor: 8.739

Lens opacification by antioestrogens: tamoxifen vs ICI 182,780.

Review 1. Clear evidence that long-term, low-dose tamoxifen treatment can induce ocular toxicity. A prospective study of 63 patients.

Review 2. The pharmacology and clinical uses of tamoxifen.

3. Ocular toxicity of tamoxifen.

Review 4. Are breast tumours resistant to tamoxifen also resistant to pure antioestrogens?

5. Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer.

6. Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.

7. ATP-activated chloride channel inhibited by an antibody to P glycoprotein.

8. Differential effects of tamoxifen and I- on three distinguishable chloride currents activated in T84 intestinal cells.

Review 9. Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer.

1. Inhibition of volume-regulated anion channels in cultured endothelial cells by the anti-oestrogens clomiphene and nafoxidine.

2. Protective effects of estrogen in a rat model of age-related cataracts.

3. Effects of anti-oestrogens and beta-estradiol on calcium uptake by cardiac sarcoplasmic reticulum.

Review 4. Can drugs or micronutrients prevent cataract?

5. Inhibition of a cardiac sarcoplasmic reticulum chloride channel by tamoxifen.

Review 6. Breast cancer medications and vision: effects of treatments for early-stage disease.