Literature DB >> 8563165

Mouse tetranectin: cDNA sequence, tissue-specific expression, and chromosomal mapping.

K Ibaraki1, C A Kozak, U M Wewer, R Albrechtsen, M F Young.   

Abstract

Tetranectin is a plasminogen-binding tetrameric protein originally isolated from plasma. Expression of tetranectin appears ubiquitous, although particularly high expression is noted in the stroma of malignant tumors and during mineralization. To dissect the molecular basis of tetranectin gene regulation, mouse tetranectin cDNA was cloned from a 16-day-old mouse embryo library. Sequence analysis revealed a 992-bp cDNA with an open reading frame of 606 bp, which is identical in length to the human tetranectin cDNA. The deduced amino acid sequence showed high homology to the human cDNA with 76% identity and 87% similarity at the amino acid level. Sequence comparisons between mouse and human tetranectin and some C-type lectins confirmed a complete conservation in the position of six cysteines as well as numerous other amino acid residues, indicating an essential structure for potential function(s) of tetranectin. The sequence analysis revealed a difference in both sequence and size of the noncoding regions between mouse and human cDNAs. Northern analysis of the various tissues from mouse, rat, and cow showed the major transcript(s) to be approximately 1 kb, which is similar in size to that observed in human. Although additional minor bands of 1.5 and 3.3 kb were found in Northern blots, RT-PCR (reverse transcription polymerase chain reaction) analysis failed to provide evidence that these minor bands are products of the tetranectin gene. Finally, the genetic map location for this gene, Tna, was determined to be on distal mouse Chromosome (Chr) 9 by analysis of two sets of multilocus crosses.

Entities:  

Mesh:

Substances:

Year:  1995        PMID: 8563165     DOI: 10.1007/bf00354289

Source DB:  PubMed          Journal:  Mamm Genome        ISSN: 0938-8990            Impact factor:   2.957


  20 in total

1.  The mouse homolog of the Gibbon ape leukemia virus receptor: genetic mapping and a possible receptor function in rodents.

Authors:  M C Adamson; J Silver; C A Kozak
Journal:  Virology       Date:  1991-08       Impact factor: 3.616

Review 2.  Two distinct classes of carbohydrate-recognition domains in animal lectins.

Authors:  K Drickamer
Journal:  J Biol Chem       Date:  1988-07-15       Impact factor: 5.157

3.  Murine bone sialoprotein (BSP): cDNA cloning, mRNA expression, and genetic mapping.

Authors:  M F Young; K Ibaraki; J M Kerr; M S Lyu; C A Kozak
Journal:  Mamm Genome       Date:  1994-02       Impact factor: 2.957

4.  Tetranectin immunoreactivity in normal human tissues. An immunohistochemical study of exocrine epithelia and mesenchyme.

Authors:  L Christensen; I Clemmensen
Journal:  Histochemistry       Date:  1989

5.  Purification and characterization of a novel, oligomeric, plasminogen kringle 4 binding protein from human plasma: tetranectin.

Authors:  I Clemmensen; L C Petersen; C Kluft
Journal:  Eur J Biochem       Date:  1986-04-15

6.  Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer.

Authors:  U M Wewer; R Albrechtsen
Journal:  Lab Invest       Date:  1992-08       Impact factor: 5.662

7.  Differences in tetranectin immunoreactivity between benign and malignant breast tissue.

Authors:  L Christensen; I Clemmensen
Journal:  Histochemistry       Date:  1991

8.  Primary structure of a protein isolated from reef shark (Carcharhinus springeri) cartilage that is similar to the mammalian C-type lectin homolog, tetranectin.

Authors:  P J Neame; C N Young; J T Treep
Journal:  Protein Sci       Date:  1992-01       Impact factor: 6.725

9.  Cloning of a cDNA encoding murine tetranectin.

Authors:  C B Sørensen; L Berglund; T E Petersen
Journal:  Gene       Date:  1995-01-23       Impact factor: 3.688

10.  A potential role for tetranectin in mineralization during osteogenesis.

Authors:  U M Wewer; K Ibaraki; P Schjørring; M E Durkin; M F Young; R Albrechtsen
Journal:  J Cell Biol       Date:  1994-12       Impact factor: 10.539

View more
  4 in total

1.  Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.

Authors:  C A Kozak; L Sangameswaran
Journal:  Mamm Genome       Date:  1996-10       Impact factor: 2.957

2.  Tetranectin in slow intra- and extrafusal chicken muscle fibers.

Authors:  X Xu; B Gilpin; K Iba; A Maier; E Engvall; R Albrechtsen; U M Wewer
Journal:  J Muscle Res Cell Motil       Date:  2001       Impact factor: 2.698

3.  Mice with a targeted deletion of the tetranectin gene exhibit a spinal deformity.

Authors:  K Iba; M E Durkin; L Johnsen; E Hunziker; K Damgaard-Pedersen; H Zhang; E Engvall; R Albrechtsen; U M Wewer
Journal:  Mol Cell Biol       Date:  2001-11       Impact factor: 4.272

4.  The adipocyte-enriched secretory protein tetranectin exacerbates type 2 diabetes by inhibiting insulin secretion from β cells.

Authors:  Fen Liu; Zixin Cai; Yan Yang; George Plasko; Piao Zhao; Xiangyue Wu; Cheng Tang; Dandan Li; Ting Li; Shanbiao Hu; Lei Song; Shaojie Yu; Ran Xu; Hairong Luo; Libin Fan; Ersong Wang; Zhen Xiao; Yujiao Ji; Rong Zeng; Rongxia Li; Juli Bai; Zhiguang Zhou; Feng Liu; Jingjing Zhang
Journal:  Sci Adv       Date:  2022-09-21       Impact factor: 14.957

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.