| Literature DB >> 8562404 |
F Mathonnet1, P de Mazancourt, B Bastenaire, M Morot, N Benattar, S Beufé, J Y Borg, Y Giudicelli.
Abstract
We studied activated protein C sensitivity ratio (APC-SR), factors V and VIII activity and von Willebrand antigen in control women, women using oral contraceptives, and pregnant women at delivery. The mean APC-SR of 2.4 in pregnant women was significantly lower than the mean APC-SR value of 3.5 for both the other groups and 45% of pregnant women had a ratio below the 5th percentile of the control group. None of them carried the R506-->Q mutation. This decreased ratio at delivery appeared to be connected, at least in part, with increased VIII activity. Thus, APC-SR at delivery should not be used to detect APC resistance.Entities:
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Year: 1996 PMID： 8562404 DOI： 10.1046/j.1365-2141.1995.00271.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998