Literature DB >> 8560778

Changes in the hemagglutinin gene of the neurovirulent influenza virus strain A/NWS/33.

A C Ward1, T F de Koning-Ward.   

Abstract

The neurovirulent strain of influenza A virus, A/NWS/33, is able to infect a large range of cell types, including mouse brain cells, which are not infected by its parent, A/WS/33. This seems to be largely due to the hemagglutinin of A/NWS/33. The complete nucleotide sequence of the HA genes of both strains has been determined and a comparison revealed a number of changes. Analysis showed that the virulence capabilities of the NWS HA involve at least three different mechanisms: (a) loss of a glycosylation site; (b) a change at the cleavage site; and (c) a substitution in HA2, which may increase the pH of fusion.

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Year:  1995        PMID： 8560778     DOI： 10.1007/bf01702599

Source DB:  PubMed          Journal:  Virus Genes        ISSN： 0920-8569            Impact factor:   2.332


  26 in total

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Journal:  Methods Enzymol       Date:  1976       Impact factor: 1.600

2.  Correlation of pathogenicity and gene constellation of influenza A viruses. II. Highly neurovirulent recombinants derived from non-neurovirulent or weakly neurovirulent parent virus strains.

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Journal:  Virology       Date:  1979-06       Impact factor: 3.616

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Journal:  Eur J Biochem       Date:  1978-04-17

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Authors:  S Nakajima; A Sugiura
Journal:  Virology       Date:  1980-03       Impact factor: 3.616

5.  Nonlinkage of neurovirulence exclusively to viral hemagglutinin or neuraminidase in genetic recombinants of A-NWS (HON1) influenza virus.

Authors:  V Mayer; J L Schulman; E D Kilbourne
Journal:  J Virol       Date:  1973-02       Impact factor: 5.103

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Journal:  J Gen Virol       Date:  1979-07       Impact factor: 3.891

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Authors:  J Bonin; C Scholtissek
Journal:  Arch Virol       Date:  1983       Impact factor: 2.574

8.  Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160.

Authors:  S Hallenberger; V Bosch; H Angliker; E Shaw; H D Klenk; W Garten
Journal:  Nature       Date:  1992-11-26       Impact factor: 49.962

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Authors:  J L Schulman; P Palese
Journal:  J Virol       Date:  1977-10       Impact factor: 5.103

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Authors:  F Yamamoto; K Maeno; S Shibata; M Iinuma; A Miyama; Y Kawamoto
Journal:  J Gen Virol       Date:  1987-04       Impact factor: 3.891
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  8 in total

Review 1.  Virulence of influenza A virus for mouse lung.

Authors:  A C Ward
Journal:  Virus Genes       Date:  1997       Impact factor: 2.332

2.  Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity.

Authors:  Sweety Samal; Sunil K Khattar; Sachin Kumar; Peter L Collins; Siba K Samal
Journal:  J Virol       Date:  2011-12-28       Impact factor: 5.103

3.  Changes in the neuraminidase of neurovirulent influenza virus strains.

Authors:  A C Ward
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332

4.  Increased acid stability of the hemagglutinin protein enhances H5N1 influenza virus growth in the upper respiratory tract but is insufficient for transmission in ferrets.

Authors:  Hassan Zaraket; Olga A Bridges; Susu Duan; Tatiana Baranovich; Sun-Woo Yoon; Mark L Reed; Rachelle Salomon; Richard J Webby; Robert G Webster; Charles J Russell
Journal:  J Virol       Date:  2013-07-03       Impact factor: 5.103

5.  The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus replication and pathogenesis in mice.

Authors:  Hassan Zaraket; Olga A Bridges; Charles J Russell
Journal:  J Virol       Date:  2013-02-28       Impact factor: 5.103

6.  Loss of N-linked glycosylation from the hemagglutinin-neuraminidase protein alters virulence of Newcastle disease virus.

Authors:  Aruna Panda; Subbiah Elankumaran; Sateesh Krishnamurthy; Zhuhui Huang; Siba K Samal
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

7.  Fecal influenza in mammals: selection of novel variants.

Authors:  Zeynep A Koçer; John Obenauer; Hassan Zaraket; Jinghui Zhang; Jerold E Rehg; Charles J Russell; Robert G Webster
Journal:  J Virol       Date:  2013-08-21       Impact factor: 5.103

8.  Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus.

Authors:  John C Kash; Christopher F Basler; Adolfo García-Sastre; Victoria Carter; Rosalind Billharz; David E Swayne; Ronald M Przygodzki; Jeffery K Taubenberger; Michael G Katze; Terrence M Tumpey
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103
  8 in total

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