| Literature DB >> 8557605 |
T Sakai1, H Kawai, M Kamishohara, A Odagawa, A Suzuki, T Uchida, T Kawasaki, T Tsuruo, N Otake.
Abstract
New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.Entities:
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Year: 1995 PMID： 8557605 DOI： 10.7164/antibiotics.48.1467
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649