Literature DB >> 8557602

Rakicidins, new cytotoxic lipopeptides from Micromonospora sp. fermentation, isolation and characterization.

K D McBrien1, R L Berry, S E Lowe, K M Neddermann, I Bursuker, S Huang, S E Klohr, J E Leet.   

Abstract

The new cytotoxic agents rakicidins A and B were isolated from cultured broth of a Micromonospora sp. Spectroscopic and amino acid analysis has shown that rakicidin A is a new cyclic lipopeptide, consisting of 4-amino-penta-2,4-dienoic acid, 3-hydroxy-2,4,16-trimethyl-heptadecanoic acid, sarcosine, and 3-hydroxyasparagine. Rakicidin B differs by one methylene group in the lipid side chain. These compounds exhibited cytotoxicity against the M109 cell line.

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Year:  1995        PMID： 8557602     DOI： 10.7164/antibiotics.48.1446

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  10 in total

1.  Comprehensive investigation of marine Actinobacteria associated with the sponge Halichondria panicea.

Authors:  Imke Schneemann; Kerstin Nagel; Inga Kajahn; Antje Labes; Jutta Wiese; Johannes F Imhoff
Journal:  Appl Environ Microbiol       Date:  2010-04-09       Impact factor: 4.792

2.  Synthesis of ent-BE-43547A1 reveals a potent hypoxia-selective anticancer agent and uncovers the biosynthetic origin of the APD-CLD natural products.

Authors:  Nikolaj L Villadsen; Kristian M Jacobsen; Ulrik B Keiding; Esben T Weibel; Bjørn Christiansen; Thomas Vosegaard; Morten Bjerring; Frank Jensen; Mogens Johannsen; Thomas Tørring; Thomas B Poulsen
Journal:  Nat Chem       Date:  2016-11-21       Impact factor: 24.427

Review 3.  The genus Micromonospora as a model microorganism for bioactive natural product discovery.

Authors:  Mohamed S Hifnawy; Mohamed M Fouda; Ahmed M Sayed; Rabab Mohammed; Hossam M Hassan; Sameh F AbouZid; Mostafa E Rateb; Alexander Keller; Martina Adamek; Nadine Ziemert; Usama Ramadan Abdelmohsen
Journal:  RSC Adv       Date:  2020-06-08       Impact factor: 4.036

4.  Rakicidin F, a new antibacterial cyclic depsipeptide from a marine sponge-derived Streptomyces sp.

Authors:  Shigeru Kitani; Tatsuya Ueguchi; Yasuhiro Igarashi; Kantinan Leetanasaksakul; Arinthip Thamchaipenet; Takuya Nihira
Journal:  J Antibiot (Tokyo)       Date:  2017-08-02       Impact factor: 2.649

5.  Draft genome sequence of Micromonospora sp. DSW705 and distribution of biosynthetic gene clusters for depsipeptides bearing 4-amino-2,4-pentadienoate in actinomycetes.

Authors:  Hisayuki Komaki; Natsuko Ichikawa; Akira Hosoyama; Moriyuki Hamada; Enjuro Harunari; Arisa Ishikawa; Yasuhiro Igarashi
Journal:  Stand Genomic Sci       Date:  2016-10-22

6.  Draft genome sequence of Streptomyces sp. MWW064 for elucidating the rakicidin biosynthetic pathway.

Authors:  Hisayuki Komaki; Arisa Ishikawa; Natsuko Ichikawa; Akira Hosoyama; Moriyuki Hamada; Enjuro Harunari; Takuya Nihira; Watanalai Panbangred; Yasuhiro Igarashi
Journal:  Stand Genomic Sci       Date:  2016-10-21

7.  Mintaimycins, a Group of Novel Peptide Metabolites from Micromonospora sp. C-3509.

Authors:  Xiaomin Hu; Ying Wang; Chunyan Zhao; Shufen Li; Xinxin Hu; Xuefu You; Jiajia Shen; Zhen Wang; Bin Hong; Bingya Jiang; Yu Du; Linzhuan Wu
Journal:  Molecules       Date:  2022-02-09       Impact factor: 4.411

Review 8.  Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review.

Authors:  Yadollah Bahrami; Sasan Bouk; Elham Kakaei; Mohammad Taheri
Journal:  Front Pharmacol       Date:  2022-07-11       Impact factor: 5.988

9.  Comparative genomics provides insights into the potential biocontrol mechanism of two Lysobacter enzymogenes strains with distinct antagonistic activities.

Authors:  Shuai Xu; Ziyu Zhang; Xuewen Xie; Yanxia Shi; Ali Chai; Tengfei Fan; Baoju Li; Lei Li
Journal:  Front Microbiol       Date:  2022-08-11       Impact factor: 6.064

Review 10.  Recent Achievements in Total Synthesis for Integral Structural Revisions of Marine Natural Products.

Authors:  Min Woo Ha; Jonghoon Kim; Seung-Mann Paek
Journal:  Mar Drugs       Date:  2022-02-25       Impact factor: 5.118
  10 in total

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