| Literature DB >> 8557596 |
K Shiomi1, H Yang, Q Xu, N Arai, M Namiki, M Hayashi, J Inokoshi, H Takeshima, R Masuma, K Komiyama.
Abstract
A new radical scavenger, named phenopyrrozin, was isolated from the culture broth of Penicillium sp. FO-2047. Phenopyrrozin was purified from whole broth solvent extraction, silica gel chromatography, and HPLC. The structure of phenopyrrozin was elucidated as 5,6,7,7a-tetrahydro-2-hydroxy-1-phenyl-3H-pyrrolizin-3-one. The IC50 of phenopyrrozin against lipid peroxidation induced by Cr2K2O7 was 73 micrograms/ml. Phenopyrrozin also reduced chromosomal aberrations induced by paraquat.Entities:
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Year: 1995 PMID： 8557596 DOI： 10.7164/antibiotics.48.1413
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649