Literature DB >> 8557573

Antibiotic GE37468 A: a novel inhibitor of bacterial protein synthesis. II. Structure elucidation.

P Ferrari1, L Colombo, S Stella, E Selva, L F Zerilli.   

Abstract

GE37468 A is a novel antibiotic produced by Streptomyces sp. ATCC 55365. It has molecular mass 1309.48 and formula C59H52O12N14S5 and belongs to the thiazolyl peptide group of antibiotics. The structure was elucidated by 1H and 13C NMR and MS studies on intact molecule and its hydrolysis products. The antibiotic is a highly modified peptide containing a macrocycle and a side chain composed of a thiazole ring and two dehydroalanine units.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 8557573     DOI： 10.7164/antibiotics.48.1304

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  Generation of thiocillin ring size variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.

Authors:  Albert A Bowers; Michael G Acker; Travis S Young; Christopher T Walsh
Journal:  J Am Chem Soc       Date:  2012-06-15       Impact factor: 15.419

2.  Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans.

Authors:  Travis S Young; Christopher T Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-25       Impact factor: 11.205

3.  Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants.

Authors:  Travis S Young; Pieter C Dorrestein; Christopher T Walsh
Journal:  Chem Biol       Date:  2012-12-21

Review 4.  YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.

Authors:  Brandon J Burkhart; Christopher J Schwalen; Greg Mann; James H Naismith; Douglas A Mitchell
Journal:  Chem Rev       Date:  2017-03-03       Impact factor: 60.622

5.  Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustris.

Authors:  Jesús Martín; Thiciana da S Sousa; Gloria Crespo; Sara Palomo; Ignacio González; José R Tormo; Mercedes de la Cruz; Matthew Anderson; Russell T Hill; Francisca Vicente; Olga Genilloud; Fernando Reyes
Journal:  Mar Drugs       Date:  2013-02-04       Impact factor: 5.118

6.  Sponge-derived Kocuria and Micrococcus spp. as sources of the new thiazolyl peptide antibiotic kocurin.

Authors:  Sara Palomo; Ignacio González; Mercedes de la Cruz; Jesús Martín; José Rubén Tormo; Matthew Anderson; Russell T Hill; Francisca Vicente; Fernando Reyes; Olga Genilloud
Journal:  Mar Drugs       Date:  2013-03-28       Impact factor: 5.118
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.