Literature DB >> 8557572

Structure determination of ribosylated rifampicin and its derivative: new inactivated metabolites of rifampicin by mycobacterial strains.

N Morisaki1, H Kobayashi, S Iwasaki, K Furihata, E R Dabbs, K Yazawa, Y Mikami.   

Abstract

Rifampicin (I) was converted into two inactivated products RIP-Ma and RIP-Mb by Mycobacterium smegmatis DSM43756. MS, NMR and chromatographic analysis showed the compounds to be 3-formyl-23-[O-(alpha-D-ribofuranosyl)]rifamycin SV (6) and 23-[O-(alpha-D-ribofuranosyl)]rifampicin (7), respectively.

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Year:  1995        PMID： 8557572     DOI： 10.7164/antibiotics.48.1299

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

1.  ADP-ribosylation as an intermediate step in inactivation of rifampin by a mycobacterial gene.

Authors:  S Quan; T Imai; Y Mikami; K Yazawa; E R Dabbs; N Morisaki; S Iwasaki; Y Hashimoto; K Furihata
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

2.  Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr.

Authors:  Jennifer Baysarowich; Kalinka Koteva; Donald W Hughes; Linda Ejim; Emma Griffiths; Kun Zhang; Murray Junop; Gerard D Wright
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-18       Impact factor: 11.205

3.  A rifampin-hypersensitive mutant reveals differences between strains of Mycobacterium smegmatis and presence of a novel transposon, IS1623.

Authors:  David C Alexander; Joses R W Jones; Jun Liu
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

4.  Integrative metagenomic and biochemical studies on rifamycin ADP-ribosyltransferases discovered in the sediment microbiome.

Authors:  Jae Hong Shin; Hyunuk Eom; Woon Ju Song; Mina Rho
Journal:  Sci Rep       Date:  2018-08-14       Impact factor: 4.379
  4 in total

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