Literature DB >> 8557521

Enhancement of phagocytosis in mouse macrophages by pituitary adenylate cyclase activating polypeptide (PACAP) and related peptides.

M Ichinose1, M Asai, K Imai, M Sawada.   

Abstract

The effects of pituitary adenylate cyclase activating polypeptide (PACAP) and related peptides on phagocytosis of fluorescent latex beads by mouse peritoneal macrophages were examined using flow cytometry (FCM). PACAP38, PACAP27 and vasoactive intestinal peptide (VIP) enhanced phagocytosis in a dose-dependent manner. Relative potencies of related peptides at a concentration of 10(-6) M were PACAP38 > PACAP27 > VIP > secretin > glucagon > (peptide with NH2-terminal histidine and COOH-terminal methionine amide, in short PHM). PACAP(6-38) was as effective as PACAP38. PACAP(6-27) enhanced phagocytosis more effectively than did PACAP27. PACAP(28-38) slightly enhanced phagocytosis. The present result suggest that PACAP38 is one of the mediators that the nervous system uses to modulate the immune system.

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Year:  1995        PMID： 8557521     DOI： 10.1016/0162-3109(95)00025-o

Source DB:  PubMed          Journal:  Immunopharmacology        ISSN： 0162-3109


  8 in total

Review 1.  Exploring the Pro-Phagocytic and Anti-Inflammatory Functions of PACAP and VIP in Microglia: Implications for Multiple Sclerosis.

Authors:  Margo I Jansen; Sarah Thomas Broome; Alessandro Castorina
Journal:  Int J Mol Sci       Date:  2022-04-26       Impact factor: 6.208

2.  Role of H2-calponin in regulating macrophage motility and phagocytosis.

Authors:  Qi-Quan Huang; M Moazzem Hossain; Kaichun Wu; Kakoli Parai; Richard M Pope; Jian-Ping Jin
Journal:  J Biol Chem       Date:  2008-07-09       Impact factor: 5.157

3.  Agonistic behavior of PACAP6-38 on sensory nerve terminals and cytotrophoblast cells.

Authors:  D Reglodi; R Borzsei; T Bagoly; A Boronkai; B Racz; A Tamas; P Kiss; G Horvath; R Brubel; J Nemeth; G Toth; Z Helyes
Journal:  J Mol Neurosci       Date:  2008-07-08       Impact factor: 3.444

4.  Phagocytic activity of splenic macrophages is enhanced and accompanied by cytosolic alkalinization in TRPM7 kinase-dead mice.

Authors:  Pavani Beesetty; Jananie Rockwood; Taku Kaitsuka; Tetyana Zhelay; Siham Hourani; Masayuki Matsushita; J Ashot Kozak
Journal:  FEBS J       Date:  2021-01-06       Impact factor: 5.622

Review 5.  Microcystin-LR Induced Immunotoxicity in Mammals.

Authors:  Yaqoob Lone; Mangla Bhide; Raj Kumar Koiri
Journal:  J Toxicol       Date:  2016-01-26

6.  Pituitary adenylate cyclase-activating polypeptide (PACAP-38) plays an inhibitory role against inflammation induced by chemical damage to zebrafish hair cells.

Authors:  Natalia Kasica-Jarosz; Piotr Podlasz; Jerzy Kaleczyc
Journal:  PLoS One       Date:  2018-06-01       Impact factor: 3.240

7.  PACAP-38 Induces Transcriptomic Changes in Rat Trigeminal Ganglion Cells Related to Neuroinflammation and Altered Mitochondrial Function Presumably via PAC1/VPAC2 Receptor-Independent Mechanism.

Authors:  Krisztina Takács-Lovász; József Kun; Timea Aczél; Péter Urbán; Attila Gyenesei; Kata Bölcskei; Éva Szőke; Zsuzsanna Helyes
Journal:  Int J Mol Sci       Date:  2022-02-14       Impact factor: 5.923

8.  PACAP38 and PACAP6-38 exert cytotoxic activity against human retinoblastoma Y79 cells.

Authors:  Jakub Wojcieszak; Jolanta B Zawilska
Journal:  J Mol Neurosci       Date:  2014-02-11       Impact factor: 3.444
  8 in total

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