Literature DB >> 8557260

Mean corpuscular hemoglobin is not increased in Fmr1 knockout mice.

E Reyniers1, D R Van Bockstaele, K De Boulle, R F Kooy, C E Bakker, B A Oostra, P J Willems.   

Abstract

A slight increase in mean corpuscular hemoglobin (MCH) has been reported in erythrocytes from human fragile X patients. As it is difficult to perform case-controlled studies in patients with fragile X syndrome, we studied MCH in erythrocytes from transgenic mice with an Fmr1 knockout. None of the knockout mice showed increased MCH levels when compared with normal littermates. We conclude that it is unlikely that the FMR1 gene product has an effect on MCH.

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Year:  1996        PMID： 8557260     DOI： 10.1007/bf00218832

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  7 in total

1.  Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome.

Authors:  I Oberlé; F Rousseau; D Heitz; C Kretz; D Devys; A Hanauer; J Boué; M F Bertheas; J L Mandel
Journal:  Science       Date:  1991-05-24       Impact factor: 47.728

2.  Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome.

Authors:  A J Verkerk; M Pieretti; J S Sutcliffe; Y H Fu; D P Kuhl; A Pizzuti; O Reiner; S Richards; M F Victoria; F P Zhang
Journal:  Cell       Date:  1991-05-31       Impact factor: 41.582

3.  Developmental toxicity of gemcitabine, an antimetabolite oncolytic, administered during gestation to CD-1 mice.

Authors:  J A Eudaly; J P Tizzano; G L Higdon; G C Todd
Journal:  Teratology       Date:  1993-10

4.  Mean corpuscular hemoglobin is increased in Martin-Bell syndrome.

Authors:  U Langenbeck; J Schmidtke; I Bartels; I Hansmann; H Knüppel
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

5.  Cyclic AMP metabolism in fragile X syndrome.

Authors:  E Berry-Kravis; P R Huttenlocher
Journal:  Ann Neurol       Date:  1992-01       Impact factor: 10.422

6.  Absence of expression of the FMR-1 gene in fragile X syndrome.

Authors:  M Pieretti; F P Zhang; Y H Fu; S T Warren; B A Oostra; C T Caskey; D L Nelson
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

7.  Characterization and localization of the FMR-1 gene product associated with fragile X syndrome.

Authors:  C Verheij; C E Bakker; E de Graaff; J Keulemans; R Willemsen; A J Verkerk; H Galjaard; A J Reuser; A T Hoogeveen; B A Oostra
Journal:  Nature       Date:  1993-06-24       Impact factor: 49.962
  7 in total

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