Literature DB >> 8557253

A highly polymorphic CA/GT repeat in intron 3 of the human urokinase receptor gene (PLAUR).

M R Kohonen-Corish1, Y Wang, W F Doe.   

Abstract

We describe the first highly polymorphic microsatellite marker for the human urokinase plasminogen activator receptor gene (PLAUR). The urokinase receptor (uPAR) has a central role in cancer invasion and metastasis, which may enable the development of new anti-metastatic therapies. Analysis of the marker genotypes in colorectal cancer cell lines revealed three alleles that were not detected in a series of healthy control individuals, which encourages further genetic study of the role of uPAR in cancer.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8557253     DOI： 10.1007/bf00218847

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  12 in total

1.  The 1993-94 Généthon human genetic linkage map.

Authors:  G Gyapay; J Morissette; A Vignal; C Dib; C Fizames; P Millasseau; S Marc; G Bernardi; M Lathrop; J Weissenbach
Journal:  Nat Genet       Date:  1994-06       Impact factor: 38.330

2.  Evidence for human meiotic recombination interference obtained through construction of a short tandem repeat-polymorphism linkage map of chromosome 19.

Authors:  J L Weber; Z Wang; K Hansen; M Stephenson; C Kappel; S Salzman; P J Wilkie; B Keats; N C Dracopoli; B F Brandriff
Journal:  Am J Hum Genet       Date:  1993-11       Impact factor: 11.025

3.  Human Co115 colon carcinoma cells potentiate the degradation of laminin mediated by tissue-type plasminogen activator.

Authors:  C Tran-Thang; D Vouillamoz; E K Kruithof; B Sordat
Journal:  J Cell Physiol       Date:  1994-11       Impact factor: 6.384

4.  Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro.

Authors:  A Stahl; B M Mueller
Journal:  Cancer Res       Date:  1994-06-01       Impact factor: 12.701

5.  Microsatellite instability in cancer of the proximal colon.

Authors:  S N Thibodeau; G Bren; D Schaid
Journal:  Science       Date:  1993-05-07       Impact factor: 47.728

6.  Human urokinase receptor expression is inhibited by amiloride and induced by tumor necrosis factor and phorbol ester in colon cancer cells.

Authors:  Y Wang; C J Jones; J Dang; X Liang; J E Olsen; W F Doe
Journal:  FEBS Lett       Date:  1994-10-17       Impact factor: 4.124

7.  Chromosomal localization of the human urokinase plasminogen activator receptor and plasminogen activator inhibitor type-2 genes: implications in colorectal cancer.

Authors:  G Webb; M S Baker; J Nicholl; Y Wang; G Woodrow; E Kruithof; W F Doe
Journal:  J Gastroenterol Hepatol       Date:  1994 Jul-Aug       Impact factor: 4.029

8.  Prevention of metastasis by inhibition of the urokinase receptor.

Authors:  C W Crowley; R L Cohen; B K Lucas; G Liu; M A Shuman; A D Levinson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

Review 9.  Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy?

Authors:  F Fazioli; F Blasi
Journal:  Trends Pharmacol Sci       Date:  1994-01       Impact factor: 14.819

10.  Chromosome 2p linkage analysis in hereditary non-polyposis colon cancer.

Authors:  M R Kohonen-Corish; W F Doe; D J St John; F A Macrae
Journal:  J Gastroenterol Hepatol       Date:  1995 Jan-Feb       Impact factor: 4.029
View more
  1 in total

Review 1.  Role of genetic polymorphisms in tumour angiogenesis.

Authors:  S P Balasubramanian; N J Brown; M W R Reed
Journal:  Br J Cancer       Date:  2002-11-04       Impact factor: 7.640
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.