Literature DB >> 8557250

Isolation and characterization of the human mismatch repair gene hMSH2 promoter region.

S J Scherer1, T Seib, G Seitz, S Dooley, C Welter.   

Abstract

Hereditary nonpolyposis colorectal cancer (HN-PCC) is one of man's commonest hereditary diseases. Several studies have identified four responsible genes that are involved in a process known as DNA mismatch repair; hMSH2 is the most important of these four genes. In addition to mutational analysis of these genes, investigations of transcriptional regulatory mechanisms are important. Therefore, our purpose has been to isolate the hMSH2 promoter region. Using direct sequencing of P1 recombinant DNA we have characterized 1100 bp of the hMSH2 promoter.

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Year:  1996        PMID： 8557250     DOI： 10.1007/bf00218844

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  18 in total

1.  Familial colonic cancer without antecedent polyposis.

Authors:  C R Boland; F J Troncale
Journal:  Ann Intern Med       Date:  1984-05       Impact factor: 25.391

2.  Stalking the start of colon cancer.

Authors:  R F Service
Journal:  Science       Date:  1994-03-18       Impact factor: 47.728

3.  Clues to the pathogenesis of familial colorectal cancer.

Authors:  L A Aaltonen; P Peltomäki; F S Leach; P Sistonen; L Pylkkänen; J P Mecklin; H Järvinen; S M Powell; J Jen; S R Hamilton
Journal:  Science       Date:  1993-05-07       Impact factor: 47.728

4.  Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations.

Authors:  R D Kolodner; N R Hall; J Lipford; M F Kane; M R Rao; P Morrison; L Wirth; P J Finan; J Burn; P Chapman
Journal:  Genomics       Date:  1994-12       Impact factor: 5.736

5.  Genetic instability of microsatellites in endometrial carcinoma.

Authors:  J I Risinger; A Berchuck; M F Kohler; P Watson; H T Lynch; J Boyd
Journal:  Cancer Res       Date:  1993-11-01       Impact factor: 12.701

6.  The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.

Authors:  R Fishel; M K Lescoe; M R Rao; N G Copeland; N A Jenkins; J Garber; M Kane; R Kolodner
Journal:  Cell       Date:  1993-12-03       Impact factor: 41.582

7.  Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

Authors:  P Peltomäki; R A Lothe; L A Aaltonen; L Pylkkänen; M Nyström-Lahti; R Seruca; L David; R Holm; D Ryberg; A Haugen
Journal:  Cancer Res       Date:  1993-12-15       Impact factor: 12.701

8.  Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.

Authors:  F S Leach; N C Nicolaides; N Papadopoulos; B Liu; J Jen; R Parsons; P Peltomäki; P Sistonen; L A Aaltonen; M Nyström-Lahti
Journal:  Cell       Date:  1993-12-17       Impact factor: 41.582

9.  Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.

Authors:  N C Nicolaides; N Papadopoulos; B Liu; Y F Wei; K C Carter; S M Ruben; C A Rosen; W A Haseltine; R D Fleischmann; C M Fraser
Journal:  Nature       Date:  1994-09-01       Impact factor: 49.962

10.  Microsatellite instability in Muir-Torre syndrome.

Authors:  R Honchel; K C Halling; D J Schaid; M Pittelkow; S N Thibodeau
Journal:  Cancer Res       Date:  1994-03-01       Impact factor: 12.701
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  5 in total

1.  Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study.

Authors:  Marlies J E Kempers; Roland P Kuiper; Charlotte W Ockeloen; Pierre O Chappuis; Pierre Hutter; Nils Rahner; Hans K Schackert; Verena Steinke; Elke Holinski-Feder; Monika Morak; Matthias Kloor; Reinhard Büttner; Eugene T P Verwiel; J Han van Krieken; Iris D Nagtegaal; Monique Goossens; Rachel S van der Post; Renée C Niessen; Rolf H Sijmons; Irma Kluijt; Frans B L Hogervorst; Edward M Leter; Johan J P Gille; Cora M Aalfs; Egbert J W Redeker; Frederik J Hes; Carli M J Tops; Bernadette P M van Nesselrooij; Marielle E van Gijn; Encarna B Gómez García; Diana M Eccles; David J Bunyan; Sapna Syngal; Elena M Stoffel; Julie O Culver; Melanie R Palomares; Tracy Graham; Lea Velsher; Janos Papp; Edith Oláh; Tsun L Chan; Suet Y Leung; Ad Geurts van Kessel; Lambertus A L M Kiemeney; Nicoline Hoogerbrugge; Marjolijn J L Ligtenberg
Journal:  Lancet Oncol       Date:  2010-12-08       Impact factor: 41.316

2.  DNA mismatch repair enzyme hMSH2 in malignant melanoma: increased immunoreactivity as compared to acquired melanocytic nevi and strong mRNA expression in melanoma cell lines.

Authors:  K Rass; P Gutwein; C Welter; V Meineke; W Tilgen; J Reichrath
Journal:  Histochem J       Date:  2001-08

3.  hMSH2 expression is driven by AP1-dependent regulation through phorbol-ester exposure.

Authors:  Odile Humbert; Ikbel Achour; Dominique Lautier; Guy Laurent; Bernard Salles
Journal:  Nucleic Acids Res       Date:  2003-10-01       Impact factor: 16.971

4.  Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1.

Authors:  Marjolijn J L Ligtenberg; Roland P Kuiper; Tsun Leung Chan; Monique Goossens; Konnie M Hebeda; Marsha Voorendt; Tracy Y H Lee; Danielle Bodmer; Eveline Hoenselaar; Sandra J B Hendriks-Cornelissen; Wai Yin Tsui; Chi Kwan Kong; Han G Brunner; Ad Geurts van Kessel; Siu Tsan Yuen; J Han J M van Krieken; Suet Yi Leung; Nicoline Hoogerbrugge
Journal:  Nat Genet       Date:  2008-12-21       Impact factor: 38.330

Review 5.  p53 in the DNA-Damage-Repair Process.

Authors:  Ashley B Williams; Björn Schumacher
Journal:  Cold Spring Harb Perspect Med       Date:  2016-05-02       Impact factor: 6.915
  5 in total

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