The effect of dose and the rate of stimulation on the action of rocuronium.

We studied the effect of administering multiples of the ED90 dose of rocuronium on the onset, duration and recovery index of neuromuscular block. The effect on onset time differed from that reported using train-of-four stimulation. This led us to investigate the effect of increasing the rate of ulnar nerve stimulation 10-fold. This resulted in an approximately 50% reduction in the time to complete block.