Literature DB >> 8555719

Behavioural disturbance in people with Down's syndrome and dementia.

V P Prasher1, A Filer.   

Abstract

Behavioural disturbance associated with dementia in people with Down's syndrome has not been fully researched. This study investigated such problems in demented Down's syndrome subjects and nondemented Down's syndrome controls. Changes in mood, difficulty with communication, gait deterioration, loss of self-care skills, sleep disturbance, day-time wandering and urinary incontinence were found to be associated with dementia. Problems giving the greatest cause for concern to carers were restlessness, loss of communication skills, urinary incontinence and wandering. Care provision specifically focused on management of behavioural disturbance in individuals who develop dementia is recommended.

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Year:  1995        PMID: 8555719     DOI: 10.1111/j.1365-2788.1995.tb00547.x

Source DB:  PubMed          Journal:  J Intellect Disabil Res        ISSN: 0964-2633


  18 in total

1.  Positron emission tomography of brain β-amyloid and τ levels in adults with Down syndrome.

Authors:  Linda D Nelson; Prabha Siddarth; Vladimir Kepe; Kevin E Scheibel; S C Huang; Jorge R Barrio; Gary W Small
Journal:  Arch Neurol       Date:  2011-06

2.  Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome.

Authors:  Elizabeth Head; Eric Doran; Mihaela Nistor; MaryAnn Hill; Frederick A Schmitt; Richard J Haier; Ira T Lott
Journal:  J Alzheimers Dis       Date:  2011       Impact factor: 4.472

3.  Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain.

Authors:  M Nistor; M Don; M Parekh; F Sarsoza; M Goodus; G E Lopez; C Kawas; J Leverenz; E Doran; I T Lott; M Hill; E Head
Journal:  Neurobiol Aging       Date:  2006-08-09       Impact factor: 4.673

Review 4.  Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms.

Authors:  Amelia J Anderson-Mooney; Frederick A Schmitt; Elizabeth Head; Ira T Lott; Kenneth M Heilman
Journal:  Brain Cogn       Date:  2016-02-27       Impact factor: 2.310

5.  Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B.

Authors:  Benjamin L Handen; Ann D Cohen; Umapathy Channamalappa; Peter Bulova; Sheila A Cannon; William I Cohen; Chester A Mathis; Julie C Price; William E Klunk
Journal:  Alzheimers Dement       Date:  2012-11       Impact factor: 21.566

6.  Alzheimer's Disease in Down Syndrome.

Authors:  Elizabeth Head; David Powell; Brian T Gold; Frederick A Schmitt
Journal:  Eur J Neurodegener Dis       Date:  2012-12

Review 7.  Dementia in Down syndrome: unique insights for Alzheimer disease research.

Authors:  Ira T Lott; Elizabeth Head
Journal:  Nat Rev Neurol       Date:  2019-03       Impact factor: 42.937

8.  Adults with Down syndrome have reduced cardiac response after light exercise testing.

Authors:  J C Vis; H A C M De Bruin-Bon; B J Bouma; S A Huisman; L Imschoot; K van den Brink; B J M Mulder
Journal:  Neth Heart J       Date:  2012-06       Impact factor: 2.380

9.  Aging and down syndrome.

Authors:  Elizabeth Head; Wayne Silverman; David Patterson; Ira T Lott
Journal:  Curr Gerontol Geriatr Res       Date:  2012-07-11

10.  Acute neuropsychiatric disorders in adolescents and young adults with Down syndrome: Japanese case reports.

Authors:  Keiko Akahoshi; Hiroshi Matsuda; Masuko Funahashi; Tomoyuki Hanaoka; Yasuyuki Suzuki
Journal:  Neuropsychiatr Dis Treat       Date:  2012-07-30       Impact factor: 2.570

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