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Literature DB >> 8554935

An in vitro technique for the rapid determination of drug entry into breast milk.

L J Notarianni¹, D Belk, S A Aird, P N Bennett.

Abstract

1. A simple in vitro technique that predicts drug transfer into breast milk is described. 2. Drugs of differing physical and chemical characteristics were tested. 3. The technique provides an experimental system for studying plasma to milk transfer with changing milk composition. 4. A mechanism proposing a role of milk proteins in controlling drug entry into milk is discussed.

Mesh：

Substances：
Fats
Milk Proteins

Year: 1995 PMID： 8554935 PMCID： PMC1365152 DOI： 10.1111/j.1365-2125.1995.tb04555.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

14 in total

1. Prospective evaluation of a model for the prediction of milk:plasma drug concentrations from physicochemical characteristics.

Authors: E J Begg; H C Atkinson; S B Duffull
Journal: Br J Clin Pharmacol Date: 1992-05 Impact factor: 4.335

2. Structural, histochemical and biochemical observations on horse milk-fat-globule membranes and casein micelles.

Authors: U Welsch; W Buchheim; U Schumacher; I Schinko; S Patton
Journal: Histochemistry Date: 1988

3. Prediction of drug distribution into human milk from physicochemical characteristics.

Authors: H C Atkinson; E J Begg
Journal: Clin Pharmacokinet Date: 1990-02 Impact factor: 6.447

4. Factors affecting the milk-to-plasma drug concentration ratio in lactating women: physical interactions with protein and fat.

Authors: J C Fleishaker; N Desai; P J McNamara
Journal: J Pharm Sci Date: 1987-03 Impact factor: 3.534

5. Prediction of drug concentrations in human skim milk from plasma protein binding and acid-base characteristics.

Authors: H C Atkinson; E J Begg
Journal: Br J Clin Pharmacol Date: 1988-04 Impact factor: 4.335

6. Relationship between human milk lipid-ultrafiltrate and octanol-water partition coefficients.

Authors: H C Atkinson; E J Begg
Journal: J Pharm Sci Date: 1988-09 Impact factor: 3.534

Review 7. Modelling of the passage of drugs into milk.

Authors: E J Begg; H C Atkinson
Journal: Pharmacol Ther Date: 1993-09 Impact factor: 12.310

8. Rapid method for the routine determination of caffeine and its metabolites by high-performance liquid chromatography.

Authors: P Dobrocky; P N Bennett; L J Notarianni
Journal: J Chromatogr Date: 1994-01-14

9. In vivo evaluation in the lactating rabbit of a model for xenobiotic distribution into breast milk.

Authors: J C Fleishaker; P J McNamara
Journal: J Pharmacol Exp Ther Date: 1988-03 Impact factor: 4.030

10. Possible effect of lactational period on the milk-to-plasma drug concentration ratio in lactating women: results of an in vitro evaluation.

Authors: J C Fleishaker; N Desai; P J McNamara
Journal: J Pharm Sci Date: 1989-02 Impact factor: 3.534

7 in total

7. Prediction of drug concentrations in milk during breastfeeding, integrating predictive algorithms within a physiologically-based pharmacokinetic model.

Authors: Khaled Abduljalil; Amita Pansari; Jia Ning; Masoud Jamei
Journal: CPT Pharmacometrics Syst Pharmacol Date: 2021-07-02

7 in total

An in vitro technique for the rapid determination of drug entry into breast milk.

1. Prospective evaluation of a model for the prediction of milk:plasma drug concentrations from physicochemical characteristics.

2. Structural, histochemical and biochemical observations on horse milk-fat-globule membranes and casein micelles.

3. Prediction of drug distribution into human milk from physicochemical characteristics.

4. Factors affecting the milk-to-plasma drug concentration ratio in lactating women: physical interactions with protein and fat.

5. Prediction of drug concentrations in human skim milk from plasma protein binding and acid-base characteristics.

6. Relationship between human milk lipid-ultrafiltrate and octanol-water partition coefficients.

Review 7. Modelling of the passage of drugs into milk.

8. Rapid method for the routine determination of caffeine and its metabolites by high-performance liquid chromatography.

9. In vivo evaluation in the lactating rabbit of a model for xenobiotic distribution into breast milk.

10. Possible effect of lactational period on the milk-to-plasma drug concentration ratio in lactating women: results of an in vitro evaluation.

Review 1. [Course and treatment of myasthenia gravis during pregnancy].

2. Prediction of milk/plasma drug concentration (M/P) ratio using support vector machine (SVM) method.

3. Prediction of Drug Transfer into Milk Considering Breast Cancer Resistance Protein (BCRP)-Mediated Transport.

Review 4. Treatment of epilepsy in women of reproductive age: pharmacokinetic considerations.

Review 5. Effect of pregnancy on the pharmacokinetics of antihypertensive drugs.

6. Development of an in vitro cell culture model to study milk to plasma ratios of therapeutic drugs.

7. Prediction of drug concentrations in milk during breastfeeding, integrating predictive algorithms within a physiologically-based pharmacokinetic model.