Literature DB >> 8552323

The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons.

Y Rubin1, M C LaPlaca, D H Smith, L E Thibault, R E Lenkinski.   

Abstract

We have studied the effect of relatively high concentrations of extracellular N-acetylaspartate (NAA) on the intracellular free calcium concentration [Ca2+]i in NTera2-neurons. While low concentrations of extracellular NAA (0.1, 1 mM) had no effect on the [Ca2+]i, high concentrations of extracellular NAA (3, 10 mM) elicited sharp and statistically significant elevations of [Ca2+]i. Different classes of antagonists of the N-methyl-D-aspartate (NMDA) receptor abolished the NAA induced elevations of the [Ca2+]i, indicating the involvement of the NMDA receptor in NAA-induced elevations of [Ca2+]i.

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Year:  1995        PMID： 8552323     DOI： 10.1016/0304-3940(95)12014-u

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  8 in total

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  8 in total

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