Literature DB >> 8552123

Bilateral subthalamic nucleus stimulation for severe Parkinson's disease.

P Limousin1, P Pollak, A Benazzouz, D Hoffmann, E Broussolle, J E Perret, A L Benabid.   

Abstract

Subthalamic nucleus (STN) lesions or high-frequency stimulations could improve parkinsonian symptoms in monkeys treated by MPTP. We have applied the procedure of chronic stimulation to the STN in severely disabled parkinsonian patients. This article presents the case of the first patient operated on bilaterally. Bilateral STN stimulation has greatly improved akinesia and rigidity. The benefit was maintained < or = 15 months after surgery. Unilateral stimulation induced motor effects mainly in contralateral limbs. Further studies are needed to evaluate the value of this procedure in the treatment of Parkinson's disease.

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Year:  1995        PMID： 8552123     DOI： 10.1002/mds.870100523

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  48 in total

1.  Acute and chronic effects of anteromedial globus pallidus stimulation in Parkinson's disease.

Authors:  F Durif; J J Lemaire; B Debilly; G Dordain
Journal:  J Neurol Neurosurg Psychiatry       Date:  1999-09       Impact factor: 10.154

2.  Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.

Authors:  H Awad; G W Hubert; Y Smith; A I Levey; P J Conn
Journal:  J Neurosci       Date:  2000-11-01       Impact factor: 6.167

3.  MRI directed bilateral stimulation of the subthalamic nucleus in patients with Parkinson's disease.

Authors:  N K Patel; P Plaha; K O'Sullivan; R McCarter; P Heywood; S S Gill
Journal:  J Neurol Neurosurg Psychiatry       Date:  2003-12       Impact factor: 10.154

4.  The switch of subthalamic neurons from an irregular to a bursting pattern does not solely depend on their GABAergic inputs in the anesthetic-free rat.

Authors:  Nadia Urbain; Nicolas Rentéro; Damien Gervasoni; Bernard Renaud; Guy Chouvet
Journal:  J Neurosci       Date:  2002-10-01       Impact factor: 6.167

5.  Mapping Go-No-Go performance within the subthalamic nucleus region.

Authors:  Tamara Hershey; Meghan C Campbell; Tom O Videen; Heather M Lugar; Patrick M Weaver; Johanna Hartlein; Morvarid Karimi; Samer D Tabbal; Joel S Perlmutter
Journal:  Brain       Date:  2010-09-20       Impact factor: 13.501

Review 6.  Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa.

Authors:  Yoland Smith; Thomas Wichmann; Stewart A Factor; Mahlon R DeLong
Journal:  Neuropsychopharmacology       Date:  2011-09-28       Impact factor: 7.853

7.  Human/nonhuman primate AC-PC ratio--considerations for translational brain measurements.

Authors:  Massimo S Fiandaca; Ernesto Aguilar Salegio; Dali Yin; R Mark Richardson; Francisco E Valles; Paul S Larson; Philip A Starr; Russell R Lonser; Krystof S Bankiewicz
Journal:  J Neurosci Methods       Date:  2010-12-24       Impact factor: 2.390

Review 8.  Cell replacement therapy is the remedial solution for treating Parkinson's disease.

Authors:  Venkatesan Dhivya; Vellingiri Balachandar
Journal:  Stem Cell Investig       Date:  2017-06-30

Review 9.  The role of the subthalamic nucleus in cognition.

Authors:  David B Weintraub; Kareem A Zaghloul
Journal:  Rev Neurosci       Date:  2013       Impact factor: 4.353

Review 10.  Deep Brain Stimulation for Movement Disorders of Basal Ganglia Origin: Restoring Function or Functionality?

Authors:  Thomas Wichmann; Mahlon R DeLong
Journal:  Neurotherapeutics       Date:  2016-04       Impact factor: 7.620
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