Literature DB >> 8551752

Was it an ancient gene codifying for a hairpin RNA that, by means of direct duplication, gave rise to the primitive tRNA molecule?

M Di Giulio1.   

Abstract

Some sequences of transfer RNAs (tRNAs) which are believed to possess many of the characteristics of the ancestral sequence of this molecule are constructed. Analysis of these ancestral sequences seems to indicate that: (i) self-alignment of these sequences makes it possible for the 3'-half of the reconstructed molecule to display a significant similarity to the 5'-half, thus indicating that the two halves of tRNA might be paralogous, and (ii) the 5'-half of the ancestral tRNA can reconstruct an almost perfect hairpin structure. These observations give weight to the hypothesis suggesting that the primitive tRNA molecule may have originated through direct duplication of an ancient gene codifying for a hairpin structure.

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Year:  1995        PMID: 8551752     DOI: 10.1016/S0022-5193(05)80007-4

Source DB:  PubMed          Journal:  J Theor Biol        ISSN: 0022-5193            Impact factor:   2.691


  23 in total

Review 1.  The early phases of genetic code origin: conjectures on the evolution of coded catalysis.

Authors:  Massimo Di Giulio
Journal:  Orig Life Evol Biosph       Date:  2003-10       Impact factor: 1.950

2.  The transition from noncoded to coded protein synthesis: did coding mRNAs arise from stability-enhancing binding partners to tRNA?

Authors:  Harold Stephen Bernhardt; Warren Perry Tate
Journal:  Biol Direct       Date:  2010-04-09       Impact factor: 4.540

3.  The last universal common ancestor (LUCA) and the ancestors of archaea and bacteria were progenotes.

Authors:  Massimo Di Giulio
Journal:  J Mol Evol       Date:  2010-11-16       Impact factor: 2.395

4.  tRNA creation by hairpin duplication.

Authors:  Jeremy Widmann; Massimo Di Giulio; Michael Yarus; Rob Knight
Journal:  J Mol Evol       Date:  2005-09-12       Impact factor: 2.395

5.  A comparison among the models proposed to explain the origin of the tRNA molecule: A synthesis.

Authors:  Massimo Di Giulio
Journal:  J Mol Evol       Date:  2009-06-02       Impact factor: 2.395

6.  Formal proof that the split genes of tRNAs of Nanoarchaeum equitans are an ancestral character.

Authors:  Massimo Di Giulio
Journal:  J Mol Evol       Date:  2009-09-17       Impact factor: 2.395

7.  Revisiting the operational RNA code for amino acids: Ensemble attributes and their implications.

Authors:  Shaul Shaul; Dror Berel; Yoav Benjamini; Dan Graur
Journal:  RNA       Date:  2009-12-01       Impact factor: 4.942

8.  The presence in tRNA molecule sequences of the double hairpin, an evolutionary stage through which the origin of this molecule is thought to have passed.

Authors:  Sergio Branciamore; Massimo Di Giulio
Journal:  J Mol Evol       Date:  2011-03-17       Impact factor: 2.395

9.  The beta-sheets of proteins, the biosynthetic relationships between amino acids, and the origin of the genetic code.

Authors:  M Di Giulio
Journal:  Orig Life Evol Biosph       Date:  1996-12       Impact factor: 1.950

10.  Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code.

Authors:  Harold S Bernhardt; Warren P Tate
Journal:  Biol Direct       Date:  2008-12-17       Impact factor: 4.540

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