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Literature DB >> 8550842

Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice.

T Tsujinaka¹, J Fujita, C Ebisui, M Yano, E Kominami, K Suzuki, K Tanaka, A Katsume, Y Ohsugi, H Shiozaki, M Monden.

Abstract

The muscles of IL-6 transgenic mice suffer from atrophy. Experiments were carried out on these transgenic mice to elucidate activation of proteolytic systems in the gastrocnemius muscles and blockage of this activation by treatment with the anti-mouse IL-6 receptor (mIL-6R) antibody. Muscle atrophy observed in 16-wk-old transgenic mice was completely blocked by treatment with the mIL-6R antibody. In association with muscle atrophy, enzymatic activities and mRNA levels of cathepsins (B and L) and mRNA levels of ubiquitins (poly- and mono-ubiquitins) increased, whereas the mRNA level of muscle-specific calpain (calpain 3) decreased. All these changes were completely eliminated by treatment with the mIL-6R antibody. This IL-6 receptor antibody could, therefore, be effective against muscle wasting in sepsis and cancer cachexia, where IL-6 plays an important role.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1996 PMID： 8550842 PMCID： PMC507086 DOI： 10.1172/JCI118398

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

51 in total

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Journal: Eur J Immunol Date: 1988-06 Impact factor: 5.532

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Journal: J Clin Invest Date: 1988-05 Impact factor: 14.808

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Authors: Y Bando; E Kominami; N Katunuma
Journal: J Biochem Date: 1986-07 Impact factor: 3.387

10. IgG1 plasmacytosis in interleukin 6 transgenic mice.

Authors: S Suematsu; T Matsuda; K Aozasa; S Akira; N Nakano; S Ohno; J Miyazaki; K Yamamura; T Hirano; T Kishimoto
Journal: Proc Natl Acad Sci U S A Date: 1989-10 Impact factor: 11.205

106 in total

1. JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia.

Authors: Andrea Bonetto; Tufan Aydogdu; Xiaoling Jin; Zongxiu Zhang; Rui Zhan; Leopold Puzis; Leonidas G Koniaris; Teresa A Zimmers
Journal: Am J Physiol Endocrinol Metab Date: 2012-06-05 Impact factor: 4.310

Review 2. Expression of subunits of the 19S complex and of the PA28 activator in rat skeletal muscle.

Authors: D Attaix; D Taillandier; L Combaret; C Rallière; D Larbaud; E Aurousseau; K Tanaka
Journal: Mol Biol Rep Date: 1997-03 Impact factor: 2.316

3. Molecular adaptations of neuromuscular disease-associated proteins in response to eccentric exercise in human skeletal muscle.

Authors: L Féasson; D Stockholm; D Freyssenet; I Richard; S Duguez; J S Beckmann; C Denis
Journal: J Physiol Date: 2002-08-15 Impact factor: 5.182

Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice.

1. Skeletal muscle metabolism in patients with malignant tumor.

2. Skeletal muscle and liver contain a soluble ATP + ubiquitin-dependent proteolytic system.

3. Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins.

4. Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2-dependent cell line and preparation of anti-IL 6 monoclonal antibodies.

5. The acute metabolic effects of tumor necrosis factor administration in humans.

6. Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue.

7. Molecular cloning and sequencing of cDNA for rat cathepsin L.

8. Interleukin 1 and tumor necrosis factor do not regulate protein balance in skeletal muscle.

9. Purification and tissue distribution of rat cathepsin L.

10. IgG1 plasmacytosis in interleukin 6 transgenic mice.

1. JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia.

Review 2. Expression of subunits of the 19S complex and of the PA28 activator in rat skeletal muscle.

3. Molecular adaptations of neuromuscular disease-associated proteins in response to eccentric exercise in human skeletal muscle.

Review 4. Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy.

5. Role of the renin-angiotensin system in age-related sarcopenia and diastolic dysfunction.

6. NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy.

Review 7. Anorexia in cancer: role of feeding-regulatory peptides.

Review 8. Muscle-derived interleukin-6: possible biological effects.

9. Exercise training as a treatment for chronic inflammation in the elderly.

10. Associations of interleukin-6, C-reactive protein and serum amyloid A with mortality in haemodialysis patients.