Literature DB >> 8549781

Genes encoding the beta 1 subunit of voltage-dependent Na+ channel in rat, mouse and human contain conserved introns.

S D Dib-Hajj1, S G Waxman.   

Abstract

We provide evidence in this study that the 86-bp insert in the beta 1.2 mRNA isoform of the voltage gated sodium channel is an intron. Transcripts still retaining this intron were detected in all tissues where the beta 1 gene expression was investigated. We also show that the exon/intron boundaries of the last two introns are conserved among rat, mouse and human beta 1 gene. Unlike the highly conserved cDNAs, introns in only the rat and mouse genes are highly related. The last intron is very short (86-90 bp) and is located in the 3' untranslated sequence, both uncommon properties of mammalian pre-mRNA introns.

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Year:  1995        PMID： 8549781     DOI： 10.1016/0014-5793(95)01400-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

Authors:  Volker Haufe; Juan A Camacho; Robert Dumaine; Bernd Günther; Christian Bollensdorff; Gisela Segond von Banchet; Klaus Benndorf; Thomas Zimmer
Journal:  J Physiol       Date:  2005-03-03       Impact factor: 5.182

2.  Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets.

Authors:  William J Brackenbury; Lori L Isom
Journal:  Expert Opin Ther Targets       Date:  2008-09       Impact factor: 6.902

3.  Down-regulation of transcripts for Na channel alpha-SNS in spinal sensory neurons following axotomy.

Authors:  S Dib-Hajj; J A Black; P Felts; S G Waxman
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

4.  Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy.

Authors:  Gustavo A Patino; William J Brackenbury; Yangyang Bao; Luis F Lopez-Santiago; Heather A O'Malley; Chunling Chen; Jeffrey D Calhoun; Ron G Lafrenière; Patrick Cossette; Guy A Rouleau; Lori L Isom
Journal:  J Neurosci       Date:  2011-10-12       Impact factor: 6.167

5.  Na Channel β Subunits: Overachievers of the Ion Channel Family.

Authors:  William J Brackenbury; Lori L Isom
Journal:  Front Pharmacol       Date:  2011-09-28       Impact factor: 5.810

6.  Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant.

Authors:  Amanda J Fein; Laurence S Meadows; Chunling Chen; Emily A Slat; Lori L Isom
Journal:  BMC Genomics       Date:  2007-07-10       Impact factor: 3.969

7.  Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates.

Authors:  Sameer S Chopra; Hiroshi Watanabe; Tao P Zhong; Dan M Roden
Journal:  BMC Evol Biol       Date:  2007-07-10       Impact factor: 3.260

8.  Intron retention in mRNA encoding ancillary subunit of insect voltage-gated sodium channel modulates channel expression, gating regulation and drug sensitivity.

Authors:  Céline M Bourdin; Bénédicte Moignot; Lingxin Wang; Laurence Murillo; Marjorie Juchaux; Sophie Quinchard; Bruno Lapied; Nathalie C Guérineau; Ke Dong; Christian Legros
Journal:  PLoS One       Date:  2013-08-15       Impact factor: 3.240
  8 in total

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