Literature DB >> 8549770

Human REG family genes are tandemly ordered in a 95-kilobase region of chromosome 2p12.

H Miyashita1, K Nakagawara, M Mori, Y Narushima, N Noguchi, S Moriizumi, S Takasawa, H Yonekura, T Takeuchi, H Okamoto.   

Abstract

Reg, first isolated from a rat regenerating islet cDNA library, is expressed in regenerating islet beta-cells. Recently, it has been revealed that Reg and Reg-related genes constitute a multigene family, the Reg family. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. In this study, we analyzed YAC clones containing the four genes and performed two-color FISH to determine the map order of the genes. The human REG family genes are tandemly ordered in the 95-kbp DNA region of chromosome 2p12 as follows: 2cen-HIP/PAP-RS-REG I alpha-REG I beta-ptel.

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Year:  1995        PMID： 8549770     DOI： 10.1016/0014-5793(95)01381-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element.

Authors:  Felicity J Ashcroft; Andrea Varro; Rod Dimaline; Graham J Dockray
Journal:  Biochem J       Date:  2004-07-15       Impact factor: 3.857

2.  Symbiotic bacteria direct expression of an intestinal bactericidal lectin.

Authors:  Heather L Cash; Cecilia V Whitham; Cassie L Behrendt; Lora V Hooper
Journal:  Science       Date:  2006-08-25       Impact factor: 47.728

3.  A Brief History of Pancreatic Reg: Implications as to its Clinical Importance.

Authors:  Haiyan Wu; Qinghu Zheng; Padmanabha Rengabhashyam; Michael E Zenilman
Journal:  Einstein Q J Biol Med       Date:  2000

4.  Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons.

Authors:  Shao-Qiu He; Jun-Ru Yao; Fang-Xiong Zhang; Qiong Wang; Lan Bao; Xu Zhang
Journal:  Mol Pain       Date:  2010-04-26       Impact factor: 3.395

5.  RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa.

Authors:  Meerit Kämäräinen; Kukka Heiskala; Sakari Knuutila; Marja Heiskala; Ola Winqvist; Leif C Andersson
Journal:  Am J Pathol       Date:  2003-07       Impact factor: 4.307

6.  Administration of anti-Reg I and anti-PAPII antibodies worsens pancreatitis.

Authors:  Domenico Viterbo; Gordon E Callender; Theresa DiMaio; Cathy M Mueller; Tamar Smith-Norowitz; Michael E Zenilman; Martin H Bluth
Journal:  JOP       Date:  2009-01-08

7.  Deteriorated high-fat diet-induced diabetes caused by pancreatic β-cell-specific overexpression of Reg3β gene in mice.

Authors:  Xiaoquan Xiong; Qing Li; Wei Cui; Zu-Hua Gao; Jun-Li Liu
Journal:  Endocrine       Date:  2016-06-03       Impact factor: 3.633

8.  Death from early colorectal cancer is predicted by the presence of transcripts of the REG gene family.

Authors:  R C Macadam; A I Sarela; S M Farmery; P A Robinson; A F Markham; P J Guillou
Journal:  Br J Cancer       Date:  2000-07       Impact factor: 7.640

9.  Expression of REG family genes in human inflammatory bowel diseases and its regulation.

Authors:  Chikatsugu Tsuchida; Sumiyo Sakuramoto-Tsuchida; Maiko Taked; Asako Itaya-Hironaka; Akiyo Yamauchi; Masayasu Misu; Ryogo Shobatake; Tomoko Uchiyama; Mai Makino; Irma Pujol-Autonell; Marta Vives-Pi; Chiho Ohbayashi; Shin Takasawa
Journal:  Biochem Biophys Rep       Date:  2017-10-23

10.  Krüppel-like factor 3 inhibition by mutated lncRNA Reg1cp results in human high bone mass syndrome.

Authors:  Mi Yang; Qi Guo; Hui Peng; Yu-Zhong Xiao; Ye Xiao; Yan Huang; Chang-Jun Li; Tian Su; Yun-Lin Zhang; Min-Xiang Lei; Hui-Ling Chen; Tie-Jian Jiang; Xiang-Hang Luo
Journal:  J Exp Med       Date:  2019-06-13       Impact factor: 14.307
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