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Literature DB >> 8548872

The role of the integrin vitronectin receptor, alpha v beta 3 in melanoma metastasis.

J Nip¹, P Brodt.

Abstract

Entities: Disease

Mesh：

Substances：
Receptors, Vitronectin

Year: 1995 PMID： 8548872 DOI： 10.1007/bf00690295

Source DB: PubMed Journal: Cancer Metastasis Rev ISSN： 0167-7659 Impact factor: 9.264

× No keyword cloud information.

94 in total

1. LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation.

Authors: J Herz; D E Clouthier; R E Hammer
Journal: Cell Date: 1992-10-30 Impact factor: 41.582

2. Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.

Authors: D Olson; J Pöllänen; G Høyer-Hansen; E Rønne; K Sakaguchi; T C Wun; E Appella; K Danø; F Blasi
Journal: J Biol Chem Date: 1992-05-05 Impact factor: 5.157

3. Affinity of integrins for damaged extracellular matrix: alpha v beta 3 binds to denatured collagen type I through RGD sites.

Authors: G E Davis
Journal: Biochem Biophys Res Commun Date: 1992-02-14 Impact factor: 3.575

4. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role.

Authors: K Vleminckx; L Vakaet; M Mareel; W Fiers; F van Roy
Journal: Cell Date: 1991-07-12 Impact factor: 41.582

5. Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages.

Authors: M O De Nichilo; G F Burns
Journal: Proc Natl Acad Sci U S A Date: 1993-03-15 Impact factor: 11.205

6. TGF-beta 1 stimulates expression of keratinocyte integrins during re-epithelialization of cutaneous wounds.

Authors: J Gailit; M P Welch; R A Clark
Journal: J Invest Dermatol Date: 1994-08 Impact factor: 8.551

7. Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin.

Authors: J Nip; H Shibata; D J Loskutoff; D A Cheresh; P Brodt
Journal: J Clin Invest Date: 1992-10 Impact factor: 14.808

8. Generation of cell surface-bound plasmin by cell-associated urokinase-type or secreted tissue-type plasminogen activator: a key event in melanoma cell invasiveness in vitro.

Authors: A Meissauer; M D Kramer; V Schirrmacher; G Brunner
Journal: Exp Cell Res Date: 1992-04 Impact factor: 3.905

9. Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-beta to TGF-beta.

Authors: L E Odekon; F Blasi; D B Rifkin
Journal: J Cell Physiol Date: 1994-03 Impact factor: 6.384

10. Requirement of vascular integrin alpha v beta 3 for angiogenesis.

Authors: P C Brooks; R A Clark; D A Cheresh
Journal: Science Date: 1994-04-22 Impact factor: 47.728

9 in total

Review 1. Role of the beta3 integrin subunit in human primary melanoma progression: multifunctional activities associated with alpha(v)beta3 integrin expression.

Authors: R E Seftor
Journal: Am J Pathol Date: 1998-11 Impact factor: 4.307

2. Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.

Authors: P C Brooks; R L Klemke; S Schon; J M Lewis; M A Schwartz; D A Cheresh
Journal: J Clin Invest Date: 1997-03-15 Impact factor: 14.808

The role of the integrin vitronectin receptor, alpha v beta 3 in melanoma metastasis.

1. LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation.

2. Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.

3. Affinity of integrins for damaged extracellular matrix: alpha v beta 3 binds to denatured collagen type I through RGD sites.

4. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role.

5. Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages.

6. TGF-beta 1 stimulates expression of keratinocyte integrins during re-epithelialization of cutaneous wounds.

7. Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin.

8. Generation of cell surface-bound plasmin by cell-associated urokinase-type or secreted tissue-type plasminogen activator: a key event in melanoma cell invasiveness in vitro.

9. Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-beta to TGF-beta.

10. Requirement of vascular integrin alpha v beta 3 for angiogenesis.

Review 1. Role of the beta3 integrin subunit in human primary melanoma progression: multifunctional activities associated with alpha(v)beta3 integrin expression.

2. Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.

3. CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth.

4. Murine hepatic microvascular adhesion molecule expression is inducible and has a zonal distribution.

5. Characterization of spontaneous metastasis in an aggressive breast carcinoma model using flow cytometry.

6. Regulation of integrin αV subunit expression by sulfatide in hepatocellular carcinoma cells.

7. MR imaging of mouse leptomeningeal metastases.

8. Orally active αvβ3 integrin inhibitor MK-0429 reduces melanoma metastasis.

9. Causal inference of gene regulation with subnetwork assembly from genetical genomics data.