| Literature DB >> 8548316 |
R G Thorne1, C R Emory, T A Ala, W H Frey.
Abstract
Following intranasal administration to rats, wheat germ agglutinin-horseradish peroxidase (WGA-HRP) concentrated in the olfactory nerve and glomerular layers of the olfactory bulb resulting in a mean olfactory bulb concentration of 140 nM. A negligible amount of label was detected in the olfactory bulb following intravenous administration of WGA-HRP or intranasal administration of unconjugated HRP. This is the first quantitative assessment of intraneuronal transport of a protein into the brain using the olfactory route.Entities:
Mesh：
Substances：
Year: 1995 PMID： 8548316 DOI： 10.1016/0006-8993(95)00637-6
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252