Literature DB >> 8546700

Brain accumulation of myo-inositol in the trisomy 16 mouse, an animal model of Down's syndrome.

H U Shetty1, H W Holloway, L D Acevedo, Z Galdzicki.   

Abstract

myo-Inositol and several other polyols were measured in the tissues of the trisomy 16 mouse (animal model of Down's Syndrome; human trisomy 21) and diploid controls. myo-Inositol was found to be selectively elevated in the brain of the trisomy 16 mouse. However, peripheral tissues showed no elevation. These results are consistent with the cerebrospinal fluid and plasma data reported previously on myo-inositol in Down's Syndrome subjects.

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Year:  1996        PMID： 8546700      PMCID： PMC1216899          DOI： 10.1042/bj3130031

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

1.  The free myo-inositol concentration of adult and fetal tissues of several species.

Authors:  F C BATTAGLIA; G MESCHIA; J N BLECHNER; D H BARRON
Journal:  Q J Exp Physiol Cogn Med Sci       Date:  1961-04

2.  The inositol content of foetal blood and foetal fluids.

Authors:  J D CAMPLING; D A NIXON
Journal:  J Physiol       Date:  1954-10-28       Impact factor: 5.182

3.  Systematic approach to the study of trisomy in the mouse. II.

Authors:  A Gropp; U Kolbus; D Giers
Journal:  Cytogenet Cell Genet       Date:  1975

4.  Capillary gas chromatography combined with ion trap detection for quantitative profiling of polyols in cerebrospinal fluid and plasma.

Authors:  H U Shetty; H W Holloway; S I Rapoport
Journal:  Anal Biochem       Date:  1995-01-01       Impact factor: 3.365

5.  High-affinity [3H]inositol uptake by dissociated brain cells and cultured fibroblasts from fetal mice.

Authors:  B R Fruen; B R Lester
Journal:  Neurochem Res       Date:  1991-08       Impact factor: 3.996

6.  Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein.

Authors:  H M Kwon; A Yamauchi; S Uchida; A S Preston; A Garcia-Perez; M B Burg; J S Handler
Journal:  J Biol Chem       Date:  1992-03-25       Impact factor: 5.157

Review 7.  The neuropathology of the trisomy 16 mouse.

Authors:  M L Lacey-Casem; M L Oster-Granite
Journal:  Crit Rev Neurobiol       Date:  1994

8.  Osmoregulatory changes in myo-inositol content and Na+/myo-inositol cotransport in rat cortical astrocytes.

Authors:  K Strange; F Emma; A Paredes; R Morrison
Journal:  Glia       Date:  1994-09       Impact factor: 7.452

9.  The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21.

Authors:  G T Berry; J J Mallee; H M Kwon; J S Rim; W R Mulla; M Muenke; N B Spinner
Journal:  Genomics       Date:  1995-01-20       Impact factor: 5.736

10.  Polyol profiles in Down syndrome. myo-Inositol, specifically, is elevated in the cerebrospinal fluid.

Authors:  H U Shetty; M B Schapiro; H W Holloway; S I Rapoport
Journal:  J Clin Invest       Date:  1995-02       Impact factor: 14.808
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  4 in total

1.  Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry.

Authors:  Sai P Bathena; Jiangeng Huang; Adrian A Epstein; Howard E Gendelman; Michael D Boska; Yazen Alnouti
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2012-02-28       Impact factor: 3.205

2.  Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome).

Authors:  Ana María Cárdenas; Paola Fernández-Olivares; Ignacio Díaz-Franulic; Arlek M González-Jamett; Takeshi Shimahara; Juan Segura-Aguilar; Raúl Caviedes; Pablo Caviedes
Journal:  Neurotox Res       Date:  2017-07-10       Impact factor: 3.911

3.  Two major inositol transporters and their role in cryptococcal virulence.

Authors:  Yina Wang; Tong-bao Liu; Guillaume Delmas; Steven Park; David Perlin; Chaoyang Xue
Journal:  Eukaryot Cell       Date:  2011-03-11

4.  Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex.

Authors:  Stanley I Rapoport; Christopher T Primiani; Chuck T Chen; Kwangmi Ahn; Veronica H Ryan
Journal:  PLoS One       Date:  2015-07-13       Impact factor: 3.240
  4 in total

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