Literature DB >> 8545247

CGRP antagonists enhance gastric acid secretion in 2-h pylorus-ligated rats.

K Kato1, V Martinez, S St Pierre, Y Taché.   

Abstract

The influence of calcitonin gene-related peptide (CGRP) antagonists on gastric acid secretion was investigated in rats. Intravenous injection of the CGRP receptor antagonist, CGRP(8-37) (128 nmol/kg) or the CGRP antibody #4901 (4.8 mg/kg, IV) completely prevented alpha-CGRP (3.9 nmol/kg/h)-induced inhibition of acid response to pentagastrin in urethane-anesthetized rats with gastric fistula. CGRP antibody (4.8 mg/kg, IV) increased by 93% gastric acid secretion in conscious rats with pylorus ligation for 2 h. (CGRP(8-73) (128 nmol/kg, IV) also enhanced the acid response measured 2 h after pylorus ligation in conscious rats and in urethane-anesthetized rats infused with pentagastrin by 91% and 56%, respectively. These results suggest that endogenous CGRP attenuates the gastric acid response measured 2 h after pylorus ligation.

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Year:  1995        PMID： 8545247     DOI： 10.1016/0196-9781(95)02004-g

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  6 in total

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6.  The Effect of Cochinchina momordica Seed Extract on Gastric Acid Secretion and Morphologic Change in Aged Rat Stomach.

Authors:  Hyun Jin Jo; Nayoung Kim; Ryoung Hee Nam; Hyun Chang; Joo-Hyon Kim; Ji Hyun Park; Jung Mook Kang; Dong Ho Lee; Hyun Chae Jung
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  6 in total

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