OBJECTIVE: To determine the relative frequencies of primary and reactivation tuberculosis in the urban homeless. DESIGN: Prospective evaluation of homeless tuberculosis patients. SETTING: Central Los Angeles, Calif. PATIENTS: Thirty-four homeless patients with culture-proven tuberculosis. INTERVENTIONS: IS6110-based restriction fragment length polymorphism (RFLP) analysis was performed on Mycobacterium tuberculosis isolates. If results were inconclusive, pTBN12-based RFLP analysis was performed. MAIN OUTCOME MEASURE: Clustering of M tuberculosis isolates. A cluster consisted of two or more isolates with indistinguishable RFLP patterns. RESULTS: Twenty-four of 34 homeless patients had clustered isolates in six clusters. CONCLUSIONS: The minimum percentage of cases due to primary tuberculosis in the homeless was estimated to be 53%, compared with the traditional estimate of 10% in the general population. The results suggest that primary tuberculosis caused the majority of tuberculosis cases in this population of the urban homeless in central Los Angeles.
OBJECTIVE: To determine the relative frequencies of primary and reactivation tuberculosis in the urban homeless. DESIGN: Prospective evaluation of homeless tuberculosis patients. SETTING: Central Los Angeles, Calif. PATIENTS: Thirty-four homeless patients with culture-proven tuberculosis. INTERVENTIONS: IS6110-based restriction fragment length polymorphism (RFLP) analysis was performed on Mycobacterium tuberculosis isolates. If results were inconclusive, pTBN12-based RFLP analysis was performed. MAIN OUTCOME MEASURE: Clustering of M tuberculosis isolates. A cluster consisted of two or more isolates with indistinguishable RFLP patterns. RESULTS: Twenty-four of 34 homeless patients had clustered isolates in six clusters. CONCLUSIONS: The minimum percentage of cases due to primary tuberculosis in the homeless was estimated to be 53%, compared with the traditional estimate of 10% in the general population. The results suggest that primary tuberculosis caused the majority of tuberculosis cases in this population of the urban homeless in central Los Angeles.
Authors: Manzour Hernando Hazbón; Michael Brimacombe; Miriam Bobadilla del Valle; Magali Cavatore; Marta Inírida Guerrero; Mandira Varma-Basil; Helen Billman-Jacobe; Caroline Lavender; Janet Fyfe; Lourdes García-García; Clara Inés León; Mridula Bose; Fernando Chaves; Megan Murray; Kathleen D Eisenach; José Sifuentes-Osornio; M Donald Cave; Alfredo Ponce de León; David Alland Journal: Antimicrob Agents Chemother Date: 2006-08 Impact factor: 5.191
Authors: M K Viljanen; B I Vyshnevskiy; T F Otten; E Vyshnevskaya; M Marjamäki; H Soini; P J Laippala; A V Vasilyef Journal: Eur J Clin Microbiol Infect Dis Date: 1998-03 Impact factor: 3.267