Literature DB >> 8541807

DNA methylation in mycobacteria: absence of methylation at GATC (Dam) and CCA/TGG (Dcm) sequences.

K C Hemavathy1, V Nagaraja.   

Abstract

The presence of 6-methyladenine and 5-methylcytosine at Dam (GATC) and Dcm (CCA/TGG) sites in DNA of mycobacterial species was investigated using isoschizomer restriction enzymes. In all species examined, Dam and Dcm recognition sequences were not methylated indicating the absence of these methyltransferases. On the other hand, high performance liquid chromatographic analysis of genomic DNA from Mycobacterium smegmatis and Mycobacterium tuberculosis showed significant levels of 6-methyladenine and 5-methylcytosine suggesting the presence of DNA methyltransferases other than Dam and Dcm. Occurrence of methylation was also established by a sensitive genetic assay.

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Year:  1995        PMID： 8541807     DOI： 10.1111/j.1574-695X.1995.tb00159.x

Source DB:  PubMed          Journal:  FEMS Immunol Med Microbiol        ISSN： 0928-8244


  9 in total

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7.  The interaction of mycobacterial protein Rv2966c with host chromatin is mediated through non-CpG methylation and histone H3/H4 binding.

Authors:  Garima Sharma; Sandeep Upadhyay; M Srilalitha; Vinay K Nandicoori; Sanjeev Khosla
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8.  DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis.

Authors:  Scarlet S Shell; Erin G Prestwich; Seung-Hun Baek; Rupal R Shah; Christopher M Sassetti; Peter C Dedon; Sarah M Fortune
Journal:  PLoS Pathog       Date:  2013-07-04       Impact factor: 6.823

9.  The Rate and Spectrum of Spontaneous Mutations in Mycobacterium smegmatis, a Bacterium Naturally Devoid of the Postreplicative Mismatch Repair Pathway.

Authors:  Sibel Kucukyildirim; Hongan Long; Way Sung; Samuel F Miller; Thomas G Doak; Michael Lynch
Journal:  G3 (Bethesda)       Date:  2016-07-07       Impact factor: 3.154
  9 in total

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