Effect of hemodialysis on methylprednisolone plasma levels.

The effect of hemodialysis on methylprednisolone levels in uremia was investigated. Methylprednisolone 15 mg/kg was given intravenously over a period of 20 min to five patients undergoing routine maintenance hemodialysis. Dialysis began 5 min after the infusion ended and continued for 5 h. Pre- and post-coil plasma levels and the dialysate level of methylprednisolone were measured at intervals. Dialysance averaged 18.4 +/- 6.1 ml/min, and mean half-life 149 +/- 26 min. The volume of distribution was 0.80 of body weight. The significant dialysance of methylprednisolone may require adjustment of dosage in certain clinical situations when hemodialysis is necessary for patients receiving the steroid.