| Literature DB >> 8540737 |
R Verdon1, J Polianski, C Gaudebout, C Marche, L Garry, C Carbon, J J Pocidalo.
Abstract
In the dexamethasone-treated rat model of cryptosporidiosis, paromomycin was effective at a dosage of 50 mg/kg/day or more for ileal infection and 200 mg/kg/day or more for cecal infection. At 1 and 3 weeks after treatment, a persistent infection was demonstrated in all rats. These results confirm the anticryptosporidial activity of paromomycin and underscore the limitations of this compound because of its potential toxicity at such high dosages and its inability to eradicate the infection.Entities:
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Year: 1995 PMID： 8540737 PMCID： PMC162902 DOI： 10.1128/AAC.39.9.2155
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191