Literature DB >> 8540411

Toward modeling the human physionome.

J B Bassingthwaighte1.   

Abstract

The physionome is the description of the physiological dynamics of the normal intact organism. The march of science brings us now into the era where integration of the various facets of the knowledge of biology and medicine has become a major issue. Modeling is a vehicle for the combining of information from molecular biology, biophysics, and medical biology, but must be combined with strategies for databasing the raw data with greater efficiency than is currently possible. The lessons from the genome project can be applied to the next level major projects, the morphonome and the physionome, the objective being to put integrated forms of the data into the hands of physicians and medical scientists.

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Year:  1995        PMID: 8540411      PMCID: PMC2875153          DOI: 10.1007/978-1-4615-1893-8_32

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN: 0065-2598            Impact factor:   2.622


  9 in total

1.  Effect of microvascular rarefaction on tissue oxygen delivery in hypertension.

Authors:  A S Greene; P J Tonellato; Z Zhang; J H Lombard; A W Cowley
Journal:  Am J Physiol       Date:  1992-05

Review 2.  Physiological hypotheses--intramyocardial pressure. A new concept, suggestions for measurement.

Authors:  N Westerhof
Journal:  Basic Res Cardiol       Date:  1990 Mar-Apr       Impact factor: 17.165

3.  Model of calcium-induced calcium release mechanism in cardiac cells.

Authors:  A Y Wong; A Fabiato; J B Bassingthwaighthe
Journal:  Bull Math Biol       Date:  1992-01       Impact factor: 1.758

4.  Models of the force-frequency relationship of rabbit papillary muscle.

Authors:  E A Johnson; N Shepherd
Journal:  Cardiovasc Res       Date:  1971-07       Impact factor: 10.787

Review 5.  Computer simulation of metabolism in palmitate-perfused rat heart. II. Behavior of complete model.

Authors:  M C Kohn; D Garfinkel
Journal:  Ann Biomed Eng       Date:  1983       Impact factor: 3.934

6.  Computer simulation of ischemic rat heart purine metabolism. II. Model behavior.

Authors:  M C Kohn; D Garfinkel
Journal:  Am J Physiol       Date:  1977-04

7.  A kinetic model of coronary reactive hyperemic response to transient ischemia.

Authors:  A Y Wong
Journal:  Bull Math Biol       Date:  1995-01       Impact factor: 1.758

8.  Computer simulation of metabolism in palmitate-perfused rat heart. I. Palmitate oxidation.

Authors:  M C Kohn; D Garfinkel
Journal:  Ann Biomed Eng       Date:  1983       Impact factor: 3.934

9.  A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation.

Authors:  C H Luo; Y Rudy
Journal:  Circ Res       Date:  1994-06       Impact factor: 17.367

  9 in total
  5 in total

1.  Modeling the human cardiome in silico.

Authors:  A D McCulloch
Journal:  J Nucl Cardiol       Date:  2000 Sep-Oct       Impact factor: 5.952

2.  The macro-ethics of genomics to health: the physiome project.

Authors:  James B Bassingthwaighte
Journal:  C R Biol       Date:  2003 Oct-Nov       Impact factor: 1.583

Review 3.  Computation of flow through the oesophagogastric junction.

Authors:  Barry P McMahon; Karl D Odie; Kenneth W Moloney; Hans Gregersen
Journal:  World J Gastroenterol       Date:  2007-03-07       Impact factor: 5.742

4.  Systems biology and physiome projects.

Authors:  Aleksander S Popel; Peter J Hunter
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2009 Sep-Oct

5.  Predictive Modeling and Integrative Physiology: The Physiome Projects.

Authors:  James B Bassingthwaighte
Journal:  Open Pacing Electrophysiol Ther J       Date:  2010
  5 in total

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