Literature DB >> 8539621

Protection against osmotic stress by cGMP-mediated myosin phosphorylation.

H Kuwayama1, M Ecke, G Gerisch, P J Van Haastert.   

Abstract

Conventional myosin functions universally as a generator of motive force in eukaryotic cells. Analysis of mutants of the microorganism Dictyostelium discoideum revealed that myosin also provides resistance against high external osmolarities. An osmo-induced increase of intracellular guanosine 3',5'-monophosphate was shown to mediate phosphorylation of three threonine residues on the myosin tail, which caused a relocalization of myosin required to resist osmotic stress. This redistribution of myosin allowed cells to adopt a spherical shape and may provide physical strength to withstand extensive cell shrinkage in high osmolarities.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8539621     DOI： 10.1126/science.271.5246.207

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  43 in total

1.  Generation of an isogenic collection of yeast actin mutants and identification of three interrelated phenotypes.

Authors:  J Whitacre; D Davis; K Toenjes; S Brower; A Adams
Journal:  Genetics       Date:  2001-02       Impact factor: 4.562

2.  Identification of four candidate cGMP targets in Dictyostelium.

Authors:  Jonathan M Goldberg; Leonard Bosgraaf; Peter J M Van Haastert; Janet L Smith
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-14       Impact factor: 11.205

3.  Identification and characterization of two unusual cGMP-stimulated phoshodiesterases in dictyostelium.

Authors:  Leonard Bosgraaf; Henk Russcher; Helena Snippe; Sonya Bader; Joyce Wind; Peter J M Van Haastert
Journal:  Mol Biol Cell       Date:  2002-11       Impact factor: 4.138

4.  Functions of LIM proteins in cell polarity and chemotactic motility.

Authors:  Bharat Khurana; Taruna Khurana; Nandkumar Khaire; Angelika A Noegel
Journal:  EMBO J       Date:  2002-10-15       Impact factor: 11.598

5.  Loss of the F-actin binding and vesicle-associated protein comitin leads to a phagocytosis defect.

Authors:  Thomas Schreiner; Martina R Mohrs; Rosemarie Blau-Wasser; Alfred von Krempelhuber; Michael Steinert; Michael Schleicher; Angelika A Noegel
Journal:  Eukaryot Cell       Date:  2002-12

Review 6.  Signaling pathways regulating Dictyostelium myosin II.

Authors:  Marc A De la Roche; Janet L Smith; Venkaiah Betapudi; Thomas T Egelhoff; Graham P Côté
Journal:  J Muscle Res Cell Motil       Date:  2002       Impact factor: 2.698

7.  Dictyostelium stress-activated protein kinase alpha, a novel stress-activated mitogen-activated protein kinase kinase kinase-like kinase, is important for the proper regulation of the cytoskeleton.

Authors:  Binggang Sun; Hui Ma; Richard A Firtel
Journal:  Mol Biol Cell       Date:  2003-11       Impact factor: 4.138

8.  Multiple regulatory mechanisms for the Dictyostelium Roco protein GbpC.

Authors:  Arjan Kortholt; Wouter N van Egmond; Katarzyna Plak; Leonard Bosgraaf; Ineke Keizer-Gunnink; Peter J M van Haastert
Journal:  J Biol Chem       Date:  2011-11-26       Impact factor: 5.157

9.  Reversal of cell polarity and actin-myosin cytoskeleton reorganization under mechanical and chemical stimulation.

Authors:  Jérémie Dalous; Emmanuel Burghardt; Annette Müller-Taubenberger; Franz Bruckert; Günther Gerisch; Till Bretschneider
Journal:  Biophys J       Date:  2007-09-28       Impact factor: 4.033

10.  Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response.

Authors:  Ana C P Thirone; Pam Speight; Matthew Zulys; Ori D Rotstein; Katalin Szászi; Stine F Pedersen; András Kapus
Journal:  Am J Physiol Cell Physiol       Date:  2008-12-24       Impact factor: 4.249
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.