The extracellular matrix of the Dictyostelium discoideum slug.

In this review, we detail the current understanding of the extracellular matrix (ECM) of the migratory slug phase of the cellular slime mould, Dictyostelium discoideum. We describe some structural and non-structural molecules which comprise the ECM, and how these molecules reflect both plant and animal ECM systems. We also describe zones of the multicellular slug that are known to make ECM components, including the role of the prestalk cells and the slug epithelium-like layer. Finally, we review the contributions of studies on mutants to our understanding of the ECM of D. discoideum, and relate this to differentiation and development in more complex eukaryotic systems.