BACKGROUND: It has been postulated that tumors beyond a certain size are dependent on angiogenesis, which might also be related to distant metastasis. We therefore assessed the prognostic significance of tumor microvasculature in renal cell carcinoma. METHODS: Tumor specimens from 84 patients with primary renal cell carcinoma were examined by immunohistochemical staining for factor VIII. Individual microvessels were counted in a 200 x field overlying the area of highest neovacularization. RESULTS: The mean number of microvessels in patients with metastases was significantly higher than that in patients who were disease-free for more than three years (P = 0.004). The survival of patients with less than 30 microvessels per 200 x field was significantly higher than that of patients with more than 30 microvessels per 200 x field (P = 0.007). Multivariate analyses revealed that these microvessel counts were the only significant predictor of prognosis in 45 patients with T1-2 and M0 tumors (P = 0.028). CONCLUSIONS: Assessment of tumor microvasculature is therefore probably one of the most important prognostic predictors in renal cell carcinoma.
BACKGROUND: It has been postulated that tumors beyond a certain size are dependent on angiogenesis, which might also be related to distant metastasis. We therefore assessed the prognostic significance of tumor microvasculature in renal cell carcinoma. METHODS:Tumor specimens from 84 patients with primary renal cell carcinoma were examined by immunohistochemical staining for factor VIII. Individual microvessels were counted in a 200 x field overlying the area of highest neovacularization. RESULTS: The mean number of microvessels in patients with metastases was significantly higher than that in patients who were disease-free for more than three years (P = 0.004). The survival of patients with less than 30 microvessels per 200 x field was significantly higher than that of patients with more than 30 microvessels per 200 x field (P = 0.007). Multivariate analyses revealed that these microvessel counts were the only significant predictor of prognosis in 45 patients with T1-2 and M0 tumors (P = 0.028). CONCLUSIONS: Assessment of tumor microvasculature is therefore probably one of the most important prognostic predictors in renal cell carcinoma.
Authors: Amparo Ruiz-Saurí; V García-Bustos; E Granero; S Cuesta; M A Sales; V Marcos; A Llombart-Bosch Journal: Pathol Oncol Res Date: 2017-07-01 Impact factor: 3.201
Authors: Atin Saha; Kyung K Peck; Eric Lis; Andrei I Holodny; Yoshiya Yamada; Sasan Karimi Journal: Spine (Phila Pa 1976) Date: 2014-11-15 Impact factor: 3.468
Authors: Mohammad Ghassem Mohseni; Abdolreza Mohammadi; Amir Said Heshmat; Farid Kosari; Ali Pasha Meysamie Journal: Int Urol Nephrol Date: 2009-05-16 Impact factor: 2.370