Comorbidity risk parameters associated with advanced breast cancer and systemic disease. Management of nonbreast disease.

The comorbidity risks associated with advanced breast cancer and systemic disease have been outlined under three broad categories: the local or regional consequences of advanced local breast cancer and its management, systemic sequelae of adjuvant chemotherapy and radiotherapy, and systemic sequelae of metastatic breast disease. Awareness of the potential risks, early detection, and active intervention may diminish the adverse consequences of comorbidities in breast cancer and improve the patient's quality of life.