| Literature DB >> 8535837 |
K Matsuno1, T Senda, T Kobayashi, S Mita.
Abstract
The effects of the stereoisomers of N-allylnormetazocine (SKF-10,047) on the hippocampal cholinergic functions were compared in rats. A putative sigma 1 receptor agonist, (+)-SKF-10,047, elicited an increase of hippocampal extracellular acetylcholine level and anti-amnesic effect against scopolamine-induced memory dysfunctions in rats. These phenomena were not produced by (-)-SKF-10,047, and were reversed by haloperidol, a putative sigma 1 receptor antagonist. Such stereoselectivity and antagonism imply an involvement of sigma 1 receptors in these (+)-SKF-10,047-stimulated hippocampal cholinergic functions.Entities:
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Year: 1995 PMID： 8535837 DOI： 10.1016/0006-8993(95)00618-z
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252