OBJECTIVES: To study the body burden of cadmium and signs of tubular dysfunction in a rural population living near a closed nickel cadmium battery plant. METHODS: Cadmium and N-acetyl-beta-glucosaminidase (NAG) in urine were measured in 72 subjects who lived close to the plant. RESULTS: Residents living close to the plant had higher median urinary cadmium concentrations than those living farther away (1.01 v 0.46 nmol/mmol creatinine) and than a control group (0.2 nmol/mmol creatinine). There was a significant correlation between urinary cadmium and the excretion of NAG in urine as well as signs of tubular dysfunction in residents who excreted urinary cadmium above 0.5 nmol/mmol creatinine. CONCLUSION: Tubular dysfunction may appear in environmentally exposed subjects at lower cadmium body burdens than previously anticipated.
OBJECTIVES: To study the body burden of cadmium and signs of tubular dysfunction in a rural population living near a closed nickel cadmium battery plant. METHODS:Cadmium and N-acetyl-beta-glucosaminidase (NAG) in urine were measured in 72 subjects who lived close to the plant. RESULTS: Residents living close to the plant had higher median urinary cadmium concentrations than those living farther away (1.01 v 0.46 nmol/mmol creatinine) and than a control group (0.2 nmol/mmol creatinine). There was a significant correlation between urinary cadmium and the excretion of NAG in urine as well as signs of tubular dysfunction in residents who excreted urinary cadmium above 0.5 nmol/mmol creatinine. CONCLUSION:Tubular dysfunction may appear in environmentally exposed subjects at lower cadmium body burdens than previously anticipated.
Authors: J P Buchet; R Lauwerys; H Roels; A Bernard; P Bruaux; F Claeys; G Ducoffre; P de Plaen; J Staessen; A Amery Journal: Lancet Date: 1990-09-22 Impact factor: 79.321
Authors: Curtis W Noonan; Sara M Sarasua; Dave Campagna; Steven J Kathman; Jeffrey A Lybarger; Patricia W Mueller Journal: Environ Health Perspect Date: 2002-02 Impact factor: 9.031
Authors: L Barregård; C Svalander; A Schütz; G Westberg; G Sällsten; I Blohmé; J Mölne; P O Attman; P Haglind Journal: Environ Health Perspect Date: 1999-11 Impact factor: 9.031